Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Hamburg, Germany.
Department of Neurosurgery, University Medical Center Hamburg Eppendorf, University of Hamburg, Hamburg, Germany.
Anticancer Res. 2021 Jul;41(7):3667-3672. doi: 10.21873/anticanres.15157.
In the oral and maxillofacial area, granulomatosis with polyangiitis (GPA) can lead to extended tissue destruction.
This is a case report of a life-threatening local complication resulting from a large osseous defect in the cranial base with consecutive massive bleeding from the right internal carotid artery. Intraoperative examination and diagnostic imaging led to neuroradiological interventional treatment by embolization, and in neurosurgical and further reconstructive surgical treatment by the oral and maxillofacial surgeons. The purpose of this case report was to draw attention to the possibly life-threatening local complications of GPA and to discuss the importance of early intervention.
As a prevention strategy, regular examinations including three-dimensional radiographic diagnostic imaging are important for the early detection of complications and the possible involvement of important structures.
在口腔颌面区域，肉芽肿性多血管炎（GPA）可导致广泛的组织破坏。
本病例报告涉及颅底大骨缺损导致的危及生命的局部并发症，以及由此引发的右侧颈内动脉大量出血。术中检查和诊断性影像学检查导致神经放射介入治疗采用栓塞，以及口腔颌面外科医生进行神经外科和进一步重建手术治疗。本病例报告旨在提请人们注意 GPA 可能危及生命的局部并发症，并讨论早期干预的重要性。
作为一种预防策略，包括三维放射诊断影像学在内的定期检查对于早期发现并发症和可能涉及的重要结构非常重要。
