术后维生素 D 缺乏对结肠癌根治性手术后复发的临床影响。

Clinical Impact of Postoperative Vitamin D Deficiency on the Recurrence of Colon Cancer After Curative Surgical Resection.

机构信息

Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea.

Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

出版信息

Anticancer Res. 2021 Jul;41(7):3683-3688. doi: 10.21873/anticanres.15159.

DOI:10.21873/anticanres.15159

PMID:34230167

Abstract

BACKGROUND/AIM: There are no clinically significant cutoff values of serum vitamin D levels and time points to predict the prognosis of colon cancer, particularly in patients who underwent curative surgical resection.

PATIENTS AND METHODS

We retrospectively analyzed serum vitamin D levels in 795 patients with stages I to III colon cancer who underwent curative surgical resection.

RESULTS

Patients with vitamin D levels below 12 ng/ml at one year after surgical resection demonstrated a significantly reduced disease-free survival (DFS) than those who did not have vitamin D deficiency (p=0.01). In the multivariate analysis, an age of 70 years or older [hazard ratio (HR)=1.992; p=0.001], pathologic stage (HR=3.739; p<0.001), and vitamin D deficiency (less than 12 ng/ml) at one year after surgery (HR=0.563; p=0.020) were factors unfavorably influencing DFS.

CONCLUSION

In patients with stages I to III of colon cancer, vitamin D deficiency at one year after surgical resection was associated with increased disease relapse.

摘要

背景/目的：目前尚无血清维生素 D 水平的临床显著截断值和时间点可用于预测结肠癌的预后，尤其是在接受根治性手术切除的患者中。

患者与方法

我们回顾性分析了 795 例接受根治性手术切除的 I 期至 III 期结肠癌患者术后 1 年的血清维生素 D 水平。

结果

与未发生维生素 D 缺乏的患者相比，术后 1 年血清维生素 D 水平低于 12ng/ml 的患者疾病无复发生存（DFS）显著降低（p=0.01）。在多因素分析中，年龄 70 岁或以上（HR=1.992；p=0.001）、病理分期（HR=3.739；p<0.001）和术后 1 年维生素 D 缺乏（<12ng/ml）（HR=0.563；p=0.020）是影响 DFS 的不利因素。