266nm 激光调节 SDSCs 中 CD90 水平的创新发现。

Innovative finding of 266-nm laser regulating CD90 levels in SDSCs.

机构信息

Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan, ROC.

Academia Sinica, Taipei, Taiwan, ROC.

出版信息

Sci Rep. 2021 Jul 6;11(1):13932. doi: 10.1038/s41598-021-93508-x.

DOI:10.1038/s41598-021-93508-x

PMID:34230598

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8260621/

Abstract

We used light to irradiate skin-derived stem cells and tried to find any cellular protein alterations 24 h after illumination. A 266-nm laser with four intensities was used, and of the nine cell markers that were surveyed in our trials, only CD90 was downregulated at an intensity of 20 μJ for 10 s. Repeated illuminations from the 266-nm laser at seven intensities revealed that CD90 expression was downregulated 14.6-28.8%, depending on light intensity. The maximal effect was noted at an intensity of 30 μJ for 2 s. This innovative finding reveals that a 266-nm laser can regulate protein expression in skin-derivative stem cells.

摘要

我们用光照射皮肤来源的干细胞，并试图在光照后 24 小时找到任何细胞蛋白的变化。使用了四种强度的 266nm 激光，在我们的试验中调查的九个细胞标记物中，只有 CD90 在强度为 20μJ 的情况下被下调了 10 秒。来自 266nm 激光的七种强度的重复照射表明，CD90 的表达水平根据光强度下调了 14.6-28.8%。最大的效果是在强度为 30μJ 的情况下持续 2 秒。这一创新性发现表明，266nm 激光可以调节皮肤来源干细胞中的蛋白质表达。