Parihar Arpana, Pandita Vasundhara, Kumar Avinash, Parihar Dipesh Singh, Puranik Nidhi, Bajpai Tapas, Khan Raju
Department of Biochemistry and Genetics, Barkatullah University, Bhopal, Madhya Pradesh 462026 India.
Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute (AMPRI), Hoshangabad Road Bhopal, 462026 India.
Regen Eng Transl Med. 2022;8(2):173-199. doi: 10.1007/s40883-021-00219-w. Epub 2021 Jul 2.
Organ or cell transplantation is medically evaluated for end-stage failure saving or extending the lives of thousands of patients who are suffering from organ failure disorders. The unavailability of adequate organs for transplantation to meet the existing demand is a major challenge in the medical field. This led to day-day-increase in the number of patients on transplant waiting lists as well as in the number of patients dying while on the queue. Recently, technological advancements in the field of biogenerative engineering have the potential to regenerate tissues and, in some cases, create new tissues and organs. In this context, major advances and innovations are being made in the fields of tissue engineering and regenerative medicine which have a huge impact on the scientific community is three-dimensional bioprinting (3D bioprinting) of tissues and organs. Besides this, the decellularization of organs and using this as a scaffold for generating new organs through the recellularization process shows promising results. This review discussed about current approaches for tissue and organ engineering including methods of scaffold designing, recent advances in 3D bioprinting, organs regenerated successfully using 3D printing, and extended application of 3D bioprinting technique in the field of medicine. Besides this, information about commercially available 3D printers has also been included in this article.
Today's need for organs for the transplantation process in order to save a patient's life or to enhance the survival rate of diseased one is the prime concern among the scientific community. Recent, advances in the field of biogenerative engineering have the potential to regenerate tissues and create organs compatible with the patient's body. In this context, major advances and innovations are being made in the fields of tissue engineering and regenerative medicine which have a huge impact on the scientific community is three-dimensional bioprinting (3D bioprinting) of tissues and organs. Besides this, the decellularization of organs and using this as a scaffold for generating new organs through the recellularization process shows promising results. This review dealt with the current approaches for tissue and organ engineering including methods of scaffold designing, recent advances in 3D bioprinting, organs regenerated successfully using 3D printing, and extended application of 3D bioprinting technique in the field of medicine. Furthermore, information about commercially available 3D printers has also been included in this article.
对于终末期器官衰竭患者，医学上会评估进行器官或细胞移植，以挽救或延长成千上万患有器官衰竭疾病患者的生命。缺乏足够的可用于移植的器官以满足现有需求是医学领域的一项重大挑战。这导致移植等待名单上的患者数量日益增加，以及排队等待期间死亡的患者数量也不断上升。最近，生物再生工程领域的技术进步有潜力再生组织，在某些情况下还能创造新的组织和器官。在此背景下，组织工程和再生医学领域正在取得重大进展和创新，其中对科学界产生巨大影响的是组织和器官的三维生物打印（3D生物打印）。除此之外，对器官进行去细胞处理，并将其用作通过再细胞化过程生成新器官的支架，显示出了有前景的结果。本综述讨论了当前组织和器官工程的方法，包括支架设计方法、3D生物打印的最新进展、使用3D打印成功再生的器官，以及3D生物打印技术在医学领域的广泛应用。此外，本文还包含了有关市售3D打印机的信息。
当今为了挽救患者生命或提高患病者的存活率而对移植过程中器官的需求，是科学界最为关注的问题。最近，生物再生工程领域的进展有潜力再生组织并创造与患者身体兼容的器官。在此背景下，组织工程和再生医学领域正在取得重大进展和创新，其中对科学界产生巨大影响的是组织和器官的三维生物打印（3D生物打印）。除此之外，对器官进行去细胞处理，并将其用作通过再细胞化过程生成新器官的支架，显示出了有前景的结果。本综述探讨了当前组织和器官工程的方法，包括支架设计方法、3D生物打印的最新进展、使用3D打印成功再生的器官，以及3D生物打印技术在医学领域的广泛应用。此外，本文还包含了有关市售3D打印机的信息。
