Vonka V, Závadová H, Brůj J, Skocil V, Janout V, Uvizl M, Kotíková J
Dev Biol Stand. 1977;39:337-9.
An inactivated whole-virus vaccine was prepared from the influenza virus recombinant H0N2 and administered to two groups of subjects. A total of 1,200 subjects were vaccinated; comparable groups of subjects served as controls. From a portion of the vaccinees sera were obtained prior to vaccination and three to four weeks afterwards. Serological tests revealed development of or increase in the antibody against H0 in a great majority of the vaccinated subjects and against N2 in slightly more than half of them. Antibody response to H3 antigen was only rarely encountered. Approximately three months after vaccination an influenza epidemic caused by Victoria-like (H3N2) viruses broke out in Czechoslovakia. Numerous influenza cases occurred in the two populations followed. Morbidity was significantly lower among the vaccinated than among the control subjects, indicating a protective effect of the neuraminidase vaccine under field conditions.
一种由重组H0N2流感病毒制备的灭活全病毒疫苗被施用于两组受试者。共有1200名受试者接种了疫苗；相当数量的对照组受试者作为对照。从一部分接种者中，在接种疫苗前和接种后三到四周采集血清。血清学检测显示，绝大多数接种者体内针对H0的抗体出现或增加，超过一半的接种者体内针对N2的抗体出现或增加。对H3抗原的抗体反应很少见。接种疫苗约三个月后，由维多利亚样（H3N2）病毒引起的流感疫情在捷克斯洛伐克爆发。随后在这两个人群中出现了大量流感病例。接种疫苗者的发病率显著低于对照组受试者，表明在现场条件下神经氨酸酶疫苗具有保护作用。
