子宫珠蛋白相关蛋白1与烟雾吸入性损伤严重程度的关联。

Association of uteroglobin-related protein 1 with smoke inhalation injury severity.

作者信息

Henrich Sabrina Frighetto, Rech Tatiana Helena, Ritter Cristiane, Michels Monique, Dal-Pizzol Felipe, Friedman Gilberto

机构信息

Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.

Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.

出版信息

Rev Bras Ter Intensiva. 2021 Apr-Jun;33(2):276-281. doi: 10.5935/0103-507X.20210035.

DOI:10.5935/0103-507X.20210035

PMID:34231808

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8275074/

Abstract

OBJECTIVE

To evaluate serum uteroglobin-related protein 1 expression early after smoke inhalation injuries and its association with the severity of inhalation injury in burned patients.

METHODS

Smoke or chemical inhalation injury is associated with morbidity and mortality. The consequences of inhalation result from an inflammatory response. Uteroglobin-related protein 1 is an anti-inflammatory protein and may improve lung inflammation. We hypothesized that uteroglobin-related protein 1 levels could reflect disease severity and predict outcome in patients with inhalation injury. Sixteen patients diagnosed with acute respiratory distress syndrome secondary to smoke inhalation injury were prospectively included in the study. Plasma was collected upon intensive care unit admission and within 24 hours of the inhalation injury. Bronchoscopies were carried out in all patients to assess the severity of inhalation injury within 72 hours. Uteroglobin-related protein 1 plasma levels were determined in duplicate with enzyme-linked immunosorbent assay.

RESULTS

The mean age was 23 ± 5 years, and the inhalation injury distribution was as follows: three of grade 1, four of grade 2, and nine of grade 3. The level of uteroglobin-related protein 1 was related to inhalation severity (grade 1: 0.389 ± 0.053 arbitrary units versus grade 2: 0.474 ± 0.0423 arbitrary units versus grade 3: 0.580 ± 0.094 arbitrary units; p = 0.007).

CONCLUSION

Plasma levels of uteroglobin-related protein 1 are associated with the degree of lung inhalation injury.

摘要

目的

评估吸入烟雾损伤后早期血清子宫珠蛋白相关蛋白1的表达及其与烧伤患者吸入性损伤严重程度的关系。

方法

吸入烟雾或化学物质损伤与发病率和死亡率相关。吸入的后果源于炎症反应。子宫珠蛋白相关蛋白1是一种抗炎蛋白，可能改善肺部炎症。我们假设子宫珠蛋白相关蛋白1水平可以反映疾病严重程度并预测吸入性损伤患者的预后。16例诊断为烟雾吸入性损伤继发急性呼吸窘迫综合征的患者被前瞻性纳入研究。在重症监护病房入院时及吸入性损伤后24小时内采集血浆。所有患者均在72小时内进行支气管镜检查以评估吸入性损伤的严重程度。采用酶联免疫吸附测定法重复测定血浆中子宫珠蛋白相关蛋白1的水平。