Department of Surgery, Jikei Daisan Hospital, Tokyo, Japan.
Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Mishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Int J Clin Oncol. 2021 Oct;26(10):1929-1937. doi: 10.1007/s10147-021-01986-w. Epub 2021 Jul 7.
Osteopenia, which is defined as a decrease in bone mineral density, has been recently recognized as a metabolic and an oncological biomarker for surgery in patients with malignancy. We aimed to study the prognostic impact of osteopenia in patients with pancreatic cancer (PC) after resection.
A total of 56 patients who underwent curative resection of PC were retrospectively investigated. The skeletal muscle index at the third lumbar spine and bone mineral density at the 11th thoracic vertebra were measured using computed tomography.
Sarcopenia and osteopenia were identified in 24 (43%) and 27 (48%) patients, respectively. The overall and disease-free survival rates were significantly lower in the sarcopenia group than in the non-sarcopenia group (p < 0.01 and p < 0.01, respectively) and in the osteopenia group than in the non-osteopenia group (p < 0.01 and p < 0.01, respectively). In multivariate analysis, sarcopenia (odds ratio [OR] 4.05; 95% confidence interval [CI] 1.23-13.38; p = 0.02) was a significant independent predictor of 1-year disease-free survival. Further, sarcopenia (OR 6.00; 95% CI 1.46-24.6; p = 0.01) and osteopenia (OR 4.66; 95% CI 1.15-18.82; p = 0.03) were significant independent predictors of 2-year overall survival.
Osteopenia is a significant negative factor for 2-year overall survival after curative resection of PC.
骨质疏松症是一种骨密度降低的病症，最近被认为是恶性肿瘤患者手术的代谢和肿瘤学生物标志物。我们旨在研究骨质疏松症对接受胰腺癌（PC）根治性切除患者的预后影响。
回顾性调查了 56 例接受根治性 PC 切除术的患者。使用计算机断层扫描测量第三腰椎的骨骼肌指数和第 11 胸椎的骨矿物质密度。
分别有 24 例（43%）和 27 例（48%）患者存在肌肉减少症和骨质疏松症。肌肉减少症组的总生存率和无病生存率明显低于非肌肉减少症组（p<0.01 和 p<0.01），骨质疏松症组的总生存率和无病生存率明显低于非骨质疏松症组（p<0.01 和 p<0.01）。多变量分析显示，肌肉减少症（优势比 [OR] 4.05；95%置信区间 [CI] 1.23-13.38；p=0.02）是 1 年无病生存率的显著独立预测因子。此外，肌肉减少症（OR 6.00；95% CI 1.46-24.6；p=0.01）和骨质疏松症（OR 4.66；95% CI 1.15-18.82；p=0.03）是 2 年总生存率的显著独立预测因子。
骨质疏松症是 PC 根治性切除后 2 年总生存率的显著负性因素。
Zotero 插件