Teng Zhaowei, Zhu Yun, Yu Xiaochao, Liu Jie, Long Qing, Zeng Yong, Lu Sheng
The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, China.
Yunnan Key Laboratory of Digital Orthopedics, The First People's Hospital of Yunnan Province, Kunming, China.
PLoS One. 2021 Apr 28;16(4):e0250437. doi: 10.1371/journal.pone.0250437. eCollection 2021.
Sarcopenia is a progressive generalized skeletal muscle disorder, which may increase the risk of osteopenia. The aim of this study was to systematically review studies on the association between sarcopenia and osteopenia by pooled analysis. The PubMed and Embase databases were searched from inception to October 2020 for studies focusing on the association between sarcopenia and osteopenia. Two reviewers independently extracted data and assessed study quality. A pooled analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) using random-effects models. Subgroup analysis was conducted to explore the source of heterogeneity and the stability of outcome. A total of 25 independent studies involving 47,744 participants fulfilled the inclusion criteria. Sarcopenia significantly increased the risk of osteopenia (OR, 2.08; 95% CI, 1.66-2.60); Sensitivity analyses indicated the outcome was stable. Subgroup analyses showed that sarcopenia significantly increased osteopenia risk in each subgroup. No evidence of publication bias among the studies existed. In this study, our findings showed that sarcopenia significantly increased the risk of osteopenia. Thus, we suggest that sarcopenia can be a predictor of osteopenia risk.
肌肉减少症是一种进行性全身性骨骼肌疾病，可能会增加骨质减少的风险。本研究的目的是通过汇总分析系统评价关于肌肉减少症与骨质减少之间关联的研究。检索了PubMed和Embase数据库，从建库至2020年10月，查找关注肌肉减少症与骨质减少之间关联的研究。两名研究者独立提取数据并评估研究质量。采用随机效应模型进行汇总分析以计算比值比（OR）和95%置信区间（CI）。进行亚组分析以探讨异质性来源和结果的稳定性。共有25项涉及47744名参与者的独立研究符合纳入标准。肌肉减少症显著增加了骨质减少的风险（OR，2.08；95%CI，1.66 - 2.60）；敏感性分析表明结果是稳定的。亚组分析显示，肌肉减少症在每个亚组中均显著增加了骨质减少的风险。研究中不存在发表偏倚的证据。在本研究中，我们的发现表明肌肉减少症显著增加了骨质减少的风险。因此，我们建议肌肉减少症可作为骨质减少风险的一个预测指标。
