Yuan Chendong, Chen Mingxiang, Cai Xiaolu
Department of Vascular Surgery, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, Zhejiang 311800, China.
Department of Cardiovascular surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, Yubei 401120, China.
Biomed Pharmacother. 2021 Jul;139:111719. doi: 10.1016/j.biopha.2021.111719. Epub 2021 May 13.
Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner. PCBP2 contains three K homology domains, which are consensus RNA-binding domains that play a role in recognizing and combining with RNA and DNA. The specific structure and localization of PCBP2 lay the foundation for its multiple roles in transcriptional, posttranscriptional, and translational processes, even in iron metabolism. Numerous studies have indicated that PCBP2 expression is increased in many cancer types. PCBP2 is considered as an oncogene that promotes tumorigenesis, development of cancer cells, and metastasis. Here, we summarized the current evidence regarding PCBP2 in the proliferation, migration, invasion of cancer cells, and drug resistance, aiming to clarify the molecular mechanisms of PCBP2 in cancer. Results from this review suggest that an in-depth study of PCBP2 in cancer may provide novel biomarkers for prognostic or therapeutic purposes.
聚（rC）结合蛋白2（PCBP2）是一种RNA结合蛋白，其特征在于能够以序列特异性方式与聚（C）高亲和力相互作用。PCBP2包含三个K同源结构域，它们是共有RNA结合结构域，在识别和结合RNA及DNA中发挥作用。PCBP2的特定结构和定位为其在转录、转录后和翻译过程甚至铁代谢中的多种作用奠定了基础。大量研究表明，PCBP2在许多癌症类型中表达增加。PCBP2被认为是一种促进肿瘤发生、癌细胞发展和转移的癌基因。在此，我们总结了目前关于PCBP2在癌细胞增殖、迁移、侵袭和耐药性方面的证据，旨在阐明PCBP2在癌症中的分子机制。本综述结果表明，对PCBP2在癌症中的深入研究可能为预后或治疗目的提供新的生物标志物。
