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靶向化学去神经支配二腹肌后腹以治疗面部联动中的下颌不适。

Targeted chemodenervation of the posterior belly of the digastric muscle for the management of jaw discomfort in facial synkinesis.

作者信息

Pescarini Elena, Butler Daniel P, Perusseau-Lambert Aude, Nduka Charles, Kannan Ruben Y

机构信息

Clinic of Plastic and Reconstructive Surgery, Neuroscience Department, University of Padua; Department of Plastic and Reconstructive Surgery, Queen Victoria Hospital, East Grinstead, UK.

Department of Plastic and Reconstructive Surgery, Queen Victoria Hospital, East Grinstead, UK.

出版信息

J Plast Reconstr Aesthet Surg. 2021 Dec;74(12):3437-3442. doi: 10.1016/j.bjps.2021.05.045. Epub 2021 Jun 9.

Abstract

BACKGROUND

Botulinum toxin (BT-A) chemodenervation has been proved to significantly improve the physical and psychological well-being of patients suffering from facial synkinesis. Despite this, a cohort of patients has persistent tightness and discomfort around the angle of the jaw, which may be caused by synkinesis within the posterior belly of digastric (PBD) muscle. This study was designed to evaluate the benefits of ultrasound-guided BT-A injections into the PBD.

METHODS

Thirty-three patients with recalcitrant tightness and discomfort around the angle of the jaw, despite maximal facial therapy and platysmal chemodenervation were selected for inclusion. Patients underwent ultrasound-guided BT-A injection into the ipsilateral PBD muscle (skin puncture site 1 cm inferior and posterior to the angle of mandible). Outcomes consisted of the Facial Disability Index (FDI), Synkinesis Assessment Questionnaire (SAQ), and a visual analogue scale (VAS) designed to assess tightness and pain around the PBD when moving the jaw, swallowing, and masticating. Questionnaires were completed two weeks before and postinjection. Statistical analysis was performed using a paired t-test.

RESULTS

Nineteen patients completed the post-treatment outcome questionnaire. A statistically significant improvement was noted in the physical and social function aspects of the FDI and all aspects of the patient-reported VAS scores apart from tightness and pain on jaw retrusion and swallowing. There was no significant difference in the SAQ.

CONCLUSION

This study has demonstrated the patient-perceived benefit of ultrasound-targeted BT-A chemodenervation of PBD. This represents a low-risk treatment option that can be easily added to the repertoire of treatments offered to patients with post paralysis facial synkinesis.

摘要

背景

肉毒杆菌毒素(BT - A)化学去神经支配已被证明能显著改善面部联动患者的身心健康。尽管如此,仍有一部分患者下颌角周围持续存在紧绷感和不适感,这可能是由二腹肌后腹(PBD)肌肉内的联动引起的。本研究旨在评估超声引导下向PBD注射BT - A的益处。

方法

选取33例尽管接受了最大程度的面部治疗和颈阔肌化学去神经支配,但下颌角周围仍有顽固性紧绷感和不适感的患者纳入研究。患者接受超声引导下向同侧PBD肌肉注射BT - A(皮肤穿刺点位于下颌角下方和后方1 cm处)。观察指标包括面部残疾指数(FDI)、联动评估问卷(SAQ)以及一个视觉模拟量表(VAS),该量表用于评估下颌运动、吞咽和咀嚼时PBD周围的紧绷感和疼痛。在注射前两周和注射后完成问卷调查。采用配对t检验进行统计分析。

结果

19例患者完成了治疗后结果问卷。FDI的身体和社会功能方面以及患者报告的VAS评分的所有方面均有统计学显著改善,但下颌后缩和吞咽时的紧绷感和疼痛除外。SAQ无显著差异。

结论

本研究证明了超声靶向PBD注射BT - A进行化学去神经支配对患者有益。这是一种低风险的治疗选择,可轻松添加到为面瘫后面部联动患者提供的治疗方法中。

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