Reis Joana, Marchini Simone, De Leeuw Anthony, Slama Hichem, Leys Christophe, Delhaye Marie, Kornreich Charles, Nicolis Hélène, Delvenne Véronique
Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.
Child and Adolescent Psychiatry Department, Queen Fabiola Children's University Hospital, Brussels, Belgium.
Front Psychiatry. 2021 Jun 21;12:645679. doi: 10.3389/fpsyt.2021.645679. eCollection 2021.
Emerging adults are a particularly at-risk population in mental health. The primary aim of the study is to evaluate changes in mental health care need and quality of life during transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS). The relationship between these changes and genetic or environmental vulnerabilities and clinical dimensions representing risk and protective factors to the development of psychopathology will be analyzed. We also aim to explore how each factor plays, specifically, a role in developing internalizing and externalizing symptoms, in order to predict the most common paths of psychopathology in transitional age youth (TAY). is a multicenter prospective longitudinal cohort study. The transversal and trans-diagnostic approach consists of a dimensional evaluation: 300 youth at the age of 17 will be included in a cohort of in-patients, out-patients and control group. Participants will be assessed at baseline (T0) and 24 months later (T1). The primary objective to determine changes in self-rated Health Of The Nation Outcome Scales For Children And Adolescents (HONOSCA-SR) and WHO Quality of Life-BREF (WHOQOL-BREF) scores between T0 and T1. Pearson correlation and mediation analysis will be performed. A secondary objective analysis using mediation and moderation models with several dimensional aspects, including self-reported and cognitive measures, will be conducted to disentangle the potential relationships between the two scores. Transition from CAMHS to AMHS occurs at a crucial age in terms of the continuum between adolescent and adulthood psychopathology. This collaborative and cohesive protocol between CAMHS and AMHS represents the first national cohort study about Transition Psychiatry in French-speaking Belgium. The study protocol was approved by the Institutional Review Boards (IRB) of the three participating sites. Results will be published in peer-reviewed journals and disseminated at national and international conferences. This trial was registered in ClinicalTrials.gov (Identifier: NCT04333797) on 3 April 2020.
新兴成年人是心理健康方面特别高危的人群。该研究的主要目的是评估从儿童和青少年心理健康服务（CAMHS）过渡到成人心理健康服务（AMHS）期间心理健康护理需求和生活质量的变化。将分析这些变化与遗传或环境脆弱性以及代表精神病理学发展风险和保护因素的临床维度之间的关系。我们还旨在探讨每个因素如何具体地在发展内化和外化症状中发挥作用，以便预测过渡年龄青年（TAY）中精神病理学最常见的路径。这是一项多中心前瞻性纵向队列研究。横向和跨诊断方法包括维度评估：17岁的300名青年将被纳入住院患者、门诊患者和对照组队列。参与者将在基线（T0）和24个月后（T1）进行评估。主要目标是确定T0和T1之间儿童和青少年全国健康结果量表自评（HONOSCA-SR）和世界卫生组织生活质量简表（WHOQOL-BREF）得分的变化。将进行Pearson相关性和中介分析。将使用具有几个维度方面（包括自我报告和认知测量）的中介和调节模型进行次要目标分析，以理清两个得分之间的潜在关系。从CAMHS过渡到AMHS发生在青少年和成人精神病理学连续统一体的关键年龄。CAMHS和AMHS之间的这种协作性和连贯性方案代表了比利时法语区关于过渡精神病学的第一项全国队列研究。该研究方案已获得三个参与地点的机构审查委员会（IRB）的批准。结果将发表在同行评审期刊上，并在国内和国际会议上传播。该试验于2020年4月3日在ClinicalTrials.gov（标识符：NCT04333797）注册。
