Kassem Ahmad N, Park Changsu, Rajkumar Aarthi
Internal Medicine, MetroHealth Medical Center, Cleveland, USA.
Cureus. 2021 May 30;13(5):e15334. doi: 10.7759/cureus.15334. eCollection 2021 May.
Sickle cell disease (SCD) is a qualitative hemoglobinopathy that can cause widespread sickling and vaso-occlusive events in all organ systems. Sickle cell hepatopathy is an umbrella term for various acute and chronic pathologies of the liver as a result of sickling in SCD patients. We present below the case of a 49-year-old woman who had an acute liver failure in the setting of a hepatic crisis with recovery after exchange transfusion. Hepatic involvement in SCD may be life-threatening. Understanding the etiology and severity of hepatic involvement by sickling is necessary for appropriate treatment.
镰状细胞病（SCD）是一种定性血红蛋白病，可在所有器官系统中引起广泛的镰状化和血管闭塞事件。镰状细胞性肝病是一个统称，指镰状细胞病患者因镰状化而导致的肝脏各种急慢性病变。我们在此介绍一例49岁女性患者，该患者在肝脏危象时出现急性肝衰竭，经换血治疗后康复。镰状细胞病中的肝脏受累可能危及生命。了解镰状化导致肝脏受累的病因和严重程度对于恰当治疗是必要的。
