Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Strategic Analysis of Clinical Affairs, UPMC Insurance Services, Pittsburgh, Pennsylvania, USA.
Head Neck. 2021 Oct;43(10):3062-3075. doi: 10.1002/hed.26801. Epub 2021 Jul 8.
Little is documented regarding objective financial metrics and their impact on subjective financial toxicity in head and neck cancer (HNC) survivors.
In a cross-sectional analysis, 71 survivors with available claims data for HNC-specific out-of-pocket expenses (OOPE) completed a survey including patient-reported, subjective financial toxicity outcome tools: the Comprehensive Score for financial Toxicity (COST) and the Financial Distress Questionnaire (FDQ).
Worse COST scores were significantly associated with lower earnings at survey administration (coefficient = 3.79; 95% CI 2.63-4.95; p < 0.001); loss of earnings after diagnosis (coefficient = 6.03; 95% CI 0.53-11.52; p = 0.032); and greater annual OOPE as a proportion of earnings [log10(Annual OOPE:Earnings at survey): coefficient = -5.66; 95% CI -10.28 to -1.04; p = 0.017]. Similar results were found with FDQ.
Financial toxicity is associated with particular socioeconomic characteristics which, if understood, would assist the development of pre-treatment screening tools to detect at-risk individuals and intervene early in the HNC cancer survivorship trajectory.
关于客观财务指标及其对头颈癌 (HNC) 幸存者主观财务毒性影响的记录很少。
在一项横断面分析中，71 名幸存者提供了 HNC 特定自付费用 (OOPE) 的索赔数据，他们完成了一项调查，其中包括患者报告的主观财务毒性结果工具：全面财务毒性评分 (COST) 和财务困境问卷 (FDQ)。
COST 评分较差与调查管理时的收入较低显著相关（系数=3.79；95%CI 2.63-4.95；p<0.001）；诊断后收入损失（系数=6.03；95%CI 0.53-11.52；p=0.032）；以及年度 OOPE 占收入的比例更大[log10(年度 OOPE：调查时的收入)：系数=-5.66；95%CI-10.28 至-1.04；p=0.017]。FDQ 也得到了类似的结果。
财务毒性与特定的社会经济特征相关，如果了解这些特征，将有助于开发治疗前筛查工具，以发现高危个体，并在 HNC 癌症生存轨迹的早期进行干预。
