Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM and Engineering & Technology Research Center for Chinese Materia Medica Quality of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Food Funct. 2021 Sep 7;12(17):7607-7618. doi: 10.1039/d1fo01175h. Epub 2021 Jul 8.
Diabetic nephropathy (DN) is a microvascular complication that is becoming a worldwide public health concern. The aim of this study was to assess the effects of dietary soy isoflavone intervention on renal function and metabolic syndrome markers in DN patients. Seven databases including Medline, the Cochrane Central Register of Controlled Trials, Science Direct, Web of Science, Embase, China National Knowledge Infrastructure, and WanFang were searched for controlled trials that assessed the effects of soy isoflavone treatment in DN patients. Finally, a total of 141 patients from 7 randomized controlled trials were included. The meta-analysis showed that dietary soy isoflavones significantly decreased 24-hour urine protein, C-reactive protein (CRP), blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose (FBG) in DN patients. The standard mean difference was -2.58 (95% CI: -3.94, -1.22; P = 0.0002) for 24-hour urine protein, -0.67 (95% CI: -0.94, -0.41; P < 0.00001) for BUN, -6.16 (95% CI: -9.02, -3.31; P < 0.0001) for CRP, -0.58 (95% CI: -0.83, -0.33; P < 0.00001) for TC, -0.41 (95% CI: -0.66, -0.16; P < 0.00001) for TG, -0.68 (95% CI: -0.94, -0.42; P < 0.00001) for LDL-C, and -0.39 (95% CI: -0.68, -0.10; P = 0.008) for FBG. Therefore, soy isoflavones may ameliorate DN by significantly decreasing 24-hour urine protein, BUN, CRP, TC, TG, LDL-C, and FBG.
糖尿病肾病（DN）是一种微血管并发症，正成为全球公共卫生关注的问题。本研究旨在评估膳食大豆异黄酮干预对 DN 患者肾功能和代谢综合征标志物的影响。我们检索了 Medline、Cochrane 中心对照试验注册库、Science Direct、Web of Science、Embase、中国知网和万方数据库，以评估大豆异黄酮治疗 DN 患者的效果。最终，共有 7 项随机对照试验的 141 名患者纳入了荟萃分析。结果显示，膳食大豆异黄酮可显著降低 DN 患者的 24 小时尿蛋白、C 反应蛋白（CRP）、血尿素氮（BUN）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和空腹血糖（FBG）。标准均数差为 -2.58（95%可信区间：-3.94，-1.22；P = 0.0002），BUN 为 -0.67（95%可信区间：-0.94，-0.41；P < 0.00001），CRP 为 -6.16（95%可信区间：-9.02，-3.31；P < 0.0001），TC 为 -0.58（95%可信区间：-0.83，-0.33；P < 0.00001），TG 为 -0.41（95%可信区间：-0.66，-0.16；P < 0.00001），LDL-C 为 -0.68（95%可信区间：-0.94，-0.42；P < 0.00001），FBG 为 -0.39（95%可信区间：-0.68，-0.10；P = 0.008）。因此，大豆异黄酮可能通过显著降低 24 小时尿蛋白、BUN、CRP、TC、TG、LDL-C 和 FBG 来改善 DN。
