Welser Letícia, Lima Rodrigo Antunes, Silveira João Francisco, Andersen Lars Bo, Pfeiffer Karin Allor, Renner Jane Dagmar Pollo, Reuter Cézane Priscila
Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, RS, Brazil.
Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain.
J Pediatr Endocrinol Metab. 2021 Jul 9;34(10):1237-1246. doi: 10.1515/jpem-2021-0023. Print 2021 Oct 26.
To compare cardiometabolic risk factors of Brazilian children and adolescents with international reference values. Cardiometabolic risk factors constitute the Metabolic Syndrome, whose evaluation is important to assess pediatric populations' health and potential to experience metabolic disorders.
Cross-sectional study that included 2,250 randomly selected children and adolescents (55.6% girls), aged 6 to 17. Cardiometabolic parameters (body mass index [BMI], waist circumference [WC], systolic and diastolic blood pressures [SBP and DBP], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], TC:HDL-C ratio, triglycerides [TG], glucose and peak oxygen uptake [VOpeak]), and clustered risk scores were compared to international age- and sex-specific reference values. A clustered risk score was calculated by summing the WC, glucose, SBP, TG, and the TC:HDL-C ratio Z-scores divided by five. A second clustered was calculated including VOpeak (inverted) Z-score, but divided by six.
The clustered risk score, considering the all ages sample, was better in the Brazilian boys (-0.20 [-0.41;0.01] and -0.18 [-0.37;0.01], including or not VOpeak, respectively) but not significantly, and worse in girls (0.24 [0.05;0.43] and 0.28 [0.11;0.44], including or not VOpeak, respectively) than the international reference. Additionally, Brazilian youth had a statistically better profile in TC, LDL-C, HDL-C, TC:HDL-C ratio, and VOpeak (only girls) as well as a worse profile in BMI, WC, SBP, DBP, TG (only girls), and VOpeak (only boys).
The clustered cardiometabolic risk score (including or not VOpeak), considering the all ages sample, was better in the Brazilian boys, but not significantly, and worse in girls compared to the international reference.
比较巴西儿童和青少年的心血管代谢危险因素与国际参考值。心血管代谢危险因素构成代谢综合征，对其进行评估对于评估儿童群体的健康状况以及发生代谢紊乱的可能性具有重要意义。
横断面研究，纳入了2250名年龄在6至17岁之间随机选取的儿童和青少年（女孩占55.6%）。将心血管代谢参数（体重指数[BMI]、腰围[WC]、收缩压和舒张压[SBP和DBP]、总胆固醇[TC]、低密度脂蛋白胆固醇[LDL-C]、高密度脂蛋白胆固醇[HDL-C]、TC:HDL-C比值、甘油三酯[TG]、血糖和峰值摄氧量[VOpeak]）以及聚类风险评分与国际年龄和性别特异性参考值进行比较。通过将WC、血糖、SBP、TG以及TC:HDL-C比值的Z分数相加后除以5来计算聚类风险评分。计算第二个聚类评分时纳入VOpeak（取倒数）的Z分数，但除以6。
考虑所有年龄样本，巴西男孩的聚类风险评分（分别包括或不包括VOpeak时为-0.20[-0.41;0.01]和-0.18[-0.37;0.01]）虽未显著优于国际参考值，但比女孩（分别包括或不包括VOpeak时为0.24[0.05;0.43]和0.28[0.11;0.44]）要好。此外，巴西青少年在TC、LDL-C、HDL-C、TC:HDL-C比值和VOpeak（仅女孩）方面在统计学上表现较好，而在BMI、WC、SBP、DBP、TG（仅女孩）和VOpeak（仅男孩）方面表现较差。
考虑所有年龄样本，巴西男孩（包括或不包括VOpeak）的聚类心血管代谢风险评分虽未显著优于国际参考值，但比女孩要好。
