Chen Tiantian, Jiang Wei, He Guangming
Department of Thoracic Surgery, the 904th Hospital of the Joint Service Support Center of the Chinese People's Liberation Army, Wuxi, China.
Department of Thoracic Surgery, Taixing People's Hospital of Jiangsu Province, Taixing, China.
Ann Palliat Med. 2021 Jun;10(6):6760-6767. doi: 10.21037/apm-21-1219.
Postoperative patients with esophageal carcinoma (EC) are prone to malnutrition. Studies have shown that the incidence of malnutrition after EC surgery reaches 60-80%, and deaths due to malnutrition account for about 22%. Patients with EC need at least 3 months to establish a new dietary pattern after surgery, so short-term enteral nutrition is of great significance. The aim of the present study was to investigate the effects of family enteral nutrition (FEN) on nutritional status in elderly patients with EC after minimally invasive radical surgery (MIS).
A total of 106 elderly patients with EC, who had undergone MIS at the 904th Hospital of the Joint Service Support Center of the Chinese People's Liberation Army and Taixing People's Hospital from January 2017 to July 2019 were selected to participate in the present study and randomly divided into the observation group and control group. There were 53 cases in each group. Patients in the control group were given regular meals after they were discharged from hospital, and the observation group was given FEN support based on the intervention of the control group. Body mass index (BMI), nutritional risk screening, nutritional status, and the incidence of complications were compared between the two groups at discharge and 1 month after discharge.
The BMI of the observation group was higher than that of the control group 1 month after discharge (P<0.05). The nutritional risk ratio of the observation group was lower than that of the control group 1 month after discharge (P<0.05). Hemoglobin, serum albumin, serum total protein, transferrin, and serum prealbumin of the observation group were higher than the control group 1 month after discharge (P<0.05). There was no significant difference in the incidence of total complications between the two groups (P>0.05).
FEN could improve the nutritional status of elderly patients with EC after MIS and reduce the risk of postoperative malnutrition and incidence of complications.
Chinese Clinical Trial Registry ChiCTR2100046121.
食管癌（EC）术后患者容易出现营养不良。研究表明，EC手术后营养不良的发生率达到60%-80%，因营养不良导致的死亡约占22%。EC患者术后至少需要3个月来建立新的饮食模式，因此短期肠内营养具有重要意义。本研究旨在探讨家庭肠内营养（FEN）对老年EC患者微创根治术后营养状况的影响。
选取2017年1月至2019年7月在中国人民解放军联勤保障部队第904医院和泰兴市人民医院接受微创根治术的106例老年EC患者参与本研究，并随机分为观察组和对照组。每组各53例。对照组患者出院后给予常规饮食，观察组在对照组干预的基础上给予FEN支持。比较两组患者出院时及出院后1个月的体重指数（BMI）、营养风险筛查、营养状况及并发症发生率。
出院后1个月，观察组的BMI高于对照组（P<0.05）。出院后1个月，观察组的营养风险比低于对照组（P<0.05）。出院后1个月，观察组的血红蛋白、血清白蛋白、血清总蛋白、转铁蛋白和血清前白蛋白均高于对照组（P<0.05）。两组总并发症发生率比较，差异无统计学意义（P>0.05）。
FEN可改善老年EC患者微创根治术后的营养状况，降低术后营养不良风险及并发症发生率。
中国临床试验注册中心ChiCTR2100046121。
