Université Clermont-Auvergne, EA7280, neurology department, Clermont-Ferrand university hospital, Clermont-Ferrand, France.
Université Clermont-Auvergne, EA7280, neurology department, Clermont-Ferrand university hospital, Clermont-Ferrand, France; Ophtalmology department, Clermont-Ferrand university hospital, Clermont-Ferrand, France.
Rev Neurol (Paris). 2021 Dec;177(10):1228-1236. doi: 10.1016/j.neurol.2021.04.007. Epub 2021 Jul 5.
Visual illusions (VI) in Parkinson's disease (PD) are generally considered part of the prodrome towards fully formed visual hallucinations (VH), and classified as minor hallucinations. However, this sequential relationship has not been clearly demonstrated and very little is known about the specific phenomenology of VI in regards to VH. We aimed to describe and compare psycho-sensory modalities associated with VI and VH in PD patients.
PD patients with VI (PD-I, n=26) and VH (PD-H, n=28) were included in this case-controlled study. We compared qualitative and quantitative psycho-sensory modalities of VI and VH using the PsychoSensory hAllucinations Scale (PSAS), and demographical and clinical features of each group.
PD-I perceptions were more often colored blots (P=0.05) or objects (P=0.005) compared to PD-H. Conversely, PD-H perceptions were more often described as animals (P<0.001), occurring at night (P=0.03) compared to PD-I. The experienced phenomena were more frequent in PD-H (P=0.02), and lasted longer (P=0.02) than for PD-I, but no between-group difference was observed for other repercussion factors including negative aspect, conviction, impact, controllable nature of the perception. Passage hallucinations and sense of presence were observed in both groups with similar frequencies (respectively P=0.60 and P=0.70). Multivariate analysis adjusting for disease severity or duration confirmed these results.
VI and VH in PD have different qualitative sensory modalities, with similar quantitative repercussion for patients, and similar association with modalities such as "sense of presence and passage hallucinations", in contrast to the generally accepted classification of VI as minor VH. REGISTRATION NUMBER: clinicaltrials.gov number NCT03454269.
帕金森病（PD）中的视觉错觉（VI）通常被认为是完全形成视觉幻觉（VH）的前驱症状的一部分，并被归类为次要幻觉。然而，这种顺序关系尚未得到明确证明，对于 PD 患者的 VI 与 VH 相关的特定现象学知之甚少。我们旨在描述和比较 PD 患者 VI 和 VH 相关的心理感觉模式。
本病例对照研究纳入了 26 例 VI（PD-I）和 28 例 VH（PD-H）的 PD 患者。我们使用心理感觉幻觉量表（PSAS）比较 VI 和 VH 的定性和定量心理感觉模式，并比较每组的人口统计学和临床特征。
与 PD-H 相比，PD-I 的感知更常为彩色斑点（P=0.05）或物体（P=0.005）。相反，PD-H 的感知更常被描述为动物（P<0.001），夜间发生（P=0.03），与 PD-I 相比。PD-H 中经历的现象更频繁（P=0.02），持续时间更长（P=0.02），但两组在其他影响因素方面没有差异，包括负面方面、信念、影响、感知的可控性。在两组中都观察到了幻觉和存在感，频率相似（分别为 P=0.60 和 P=0.70）。调整疾病严重程度或持续时间的多变量分析证实了这些结果。
PD 中的 VI 和 VH 具有不同的定性感觉模式，对患者的定量影响相似，与“存在感和幻觉通过”等模式的相关性相似，与 VI 被归类为次要 VH 的一般分类相反。注册号：clinicaltrials.gov 编号 NCT03454269。
