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原发性臂丛神经肿瘤手术治疗的临床结果

Clinical Outcomes of Surgical Management of Primary Brachial Plexus Tumors.

作者信息

Gaba Sunil, Mohsina Subair, John Jerry R, Tripathy Satyaswarup, Sharma Ramesh Kumar

机构信息

Department of Plastic Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

出版信息

Indian J Plast Surg. 2021 Apr;54(2):124-129. doi: 10.1055/s-0041-1731252. Epub 2021 Jun 28.

Abstract

This study evaluates the clinical presentation, tumor characteristics, and clinical outcomes of surgically treated benign and malignant brachial plexus tumors (BPTs).  A prospective study of patients with BPTs from June 2015 to August 2020 was conducted. All patients underwent surgical resection with microneurolysis and intraoperative electrical stimulation to preserve the functioning nerve fascicles.  Fourteen patients with 15 BPTs underwent surgical resection. Mean age was 37.8 ± 12.3 years; with male to female ratio 4:10. The clinical presentations were swelling (100%), pain (84.6%), and paresthesia (76.9%). The lesions involved roots (5/15), trunk (5/15), division (1/15), and cords (4/15). Thirteen patients had benign pathology (8 schwannomas, 3 neurofibromas, 2 lipomas) and two had malignant neurofibrosarcoma. Gross total resection was achieved in all cases except a dumbbell tumor. The mean follow-up period was 24 ± 5 months. Postoperatively, all patients reported improvement in pain and paresthesia with no new sensory deficit. All patients had developed initial motor weakness (Grades 2-4); however, full power (Grade 5) was recovered by 3 to 5 months.  Total resection can be achieved by appropriate microneural dissection and electrophysiologic monitoring and is potentially curative with preserving function.

摘要

本研究评估手术治疗的良性和恶性臂丛神经肿瘤(BPTs)的临床表现、肿瘤特征及临床结局。对2015年6月至2020年8月期间的BPTs患者进行了一项前瞻性研究。所有患者均接受了显微神经松解术及术中电刺激的手术切除,以保留功能正常的神经束。14例患有15个BPTs的患者接受了手术切除。平均年龄为37.8±12.3岁;男女比例为4:10。临床表现为肿胀(100%)、疼痛(84.6%)和感觉异常(76.9%)。病变累及神经根(5/15)、神经干(5/15)、神经分支(1/15)和神经束(4/15)。13例患者病理结果为良性(8例神经鞘瘤、3例神经纤维瘤、2例脂肪瘤),2例为恶性神经纤维肉瘤。除1例哑铃形肿瘤外,所有病例均实现了肉眼下全切。平均随访期为24±5个月。术后,所有患者均报告疼痛和感觉异常有所改善,且无新的感觉功能障碍。所有患者均出现了最初的运动无力(2-4级);然而,3至5个月后恢复至完全肌力(5级)。通过适当的显微神经解剖和电生理监测可实现全切,且在保留功能的情况下可能治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2d/8257325/f20ca479e362/10-1055-s-0041-1731252_10_0884_01.jpg

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