Jacobs Nathan R, Norton Pamela A
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, United States.
World J Hepatol. 2021 Jun 27;13(6):662-672. doi: 10.4254/wjh.v13.i6.662.
Chromosome 1q often has been observed to be amplified in hepatocellular carcinoma. This review summarizes literature reports of multiple genes that have been proposed as possible 1q amplification drivers. These largely fall within 1q21-1q23. In addition, publicly available copy number alteration data from The Cancer Genome Atlas project were used to identify additional candidate genes involved in carcinogenesis. The most frequent location for gene amplification was 1q22, consistent with the results of the literature search. The genes and were found to be candidates whose amplification and/or mRNA up-regulation was most highly associated with poorer hepatocellular carcinoma outcomes.
1号染色体长臂在肝细胞癌中常被观察到发生扩增。本综述总结了多篇文献报道中被认为可能是1号染色体长臂扩增驱动因素的多个基因。这些基因大多位于1q21 - 1q23区域。此外，利用来自癌症基因组图谱项目的公开拷贝数变异数据来识别参与致癌作用的其他候选基因。基因扩增最常见的位置是1q22，这与文献检索结果一致。发现基因 和 是其扩增和/或mRNA上调与肝细胞癌较差预后最密切相关的候选基因。
