Department of Physics, Central China Normal University, Wuhan 430079, China.
Chaos. 2021 May;31(5):053102. doi: 10.1063/5.0044874.
Potassium ion and sodium ion channels play important roles in the propagation of action potentials along a myelinated axon. The random opening and closing of ion channels can cause the fluctuation of action potentials. In this paper, an improved Hodgkin-Huxley chain network model is proposed to study the effects of ion channel blocks, temperature, and ion channel noise on the propagation of action potentials along the myelinated axon. It is found that the chain network has minimum coupling intensity threshold and maximum tolerance temperature threshold that allow the action potentials to pass along the whole axon, and the blockage of ion channels can change these two thresholds. A striking result is that the simulated value of the optimum membrane size (inversely proportional to noise intensity) coincides with the area range of feline thalamocortical relay cells in biological experiments.
钾离子和钠离子通道在有髓轴突上动作电位的传播中起着重要作用。离子通道的随机开启和关闭会导致动作电位的波动。本文提出了一种改进的 Hodgkin-Huxley 链式网络模型，以研究离子通道阻断、温度和离子通道噪声对有髓轴突上动作电位传播的影响。研究发现，链式网络具有允许动作电位沿整个轴突传播的最小耦合强度阈值和最大耐受温度阈值，而离子通道的阻断会改变这两个阈值。一个显著的结果是，模拟的最佳膜大小（与噪声强度成反比）与生物实验中猫丘脑皮层中继细胞的面积范围相吻合。
