降钙素原作为 COVID-19 患者呼吸机相关性肺炎的生物标志物：它是一种有用的管理工具吗？
Procalcitonin as a biomarker for ventilator associated pneumonia in COVID-19 patients: Is it an useful stewardship tool?
机构信息
Department of Infection Diseases, LIM-49, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Open Innovation and Partnership Department at bioMérieux, São Paulo, Brazil; Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
出版信息
Diagn Microbiol Infect Dis. 2021 Oct;101(2):115344. doi: 10.1016/j.diagmicrobio.2021.115344. Epub 2021 Feb 12.
Ventilator associated pneumonia(VAP) is a severe complication that can lead to high mortality when not early identified or when therapy is delayed. The aim of this study was to evaluate procalcitonin(PCT) as a biomarker for VAP development. In total, 73 hospitalized patients with COVID-19 were analyzed. PCT levels greater than 0.975ng/mL were more related to VAP. No association was found for C-reactive protein (CRP). The results show that procalcitonin may be a pertinent biomarker for VAP diagnosis and can be a helpful tool for antibiotic withdrawal.
呼吸机相关性肺炎（VAP）是一种严重的并发症，如果不能及早发现或治疗延迟，可能导致高死亡率。本研究旨在评估降钙素原（PCT）作为 VAP 发生的生物标志物。共分析了 73 例 COVID-19 住院患者。PCT 水平大于 0.975ng/mL 与 VAP 更相关。C 反应蛋白（CRP）没有相关性。结果表明，降钙素原可能是 VAP 诊断的一个相关生物标志物，并可以作为抗生素停药的有用工具。
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