Vilnius Research Group, VIC Clinic, Vilnius, Lithuania.
VIC Clinic, Vilnius, Lithuania.
Clin Exp Dent Res. 2021 Dec;7(6):1061-1068. doi: 10.1002/cre2.468. Epub 2021 Jul 10.
It was shown, that Connective Tissue Grafts (CTG) retrieved from the tuberosity tends to determine hyperplastic responses and may induce a beneficial over-keratinization of non-keratinized mucosa. Clinically evaluate and compare CTG from tuberosity ability to increase soft tissue thickness and the keratinization potential after recipient area is either prepared using split or full thickness flap in edentulous mandible.
Fourty implants were placed in 10 edentulous patients with atrophied mandible (Class IV of Misch) presenting less than 1.0 mm of keratinized tissue using a flapless approach and immediately restored with acrylic temporary bridge on multi-unit abutments. The surgical sites were split-mouth randomized and prepared as CTG recipients by a tunneling procedure. Twenty benefited of a partial thickness approach and 20 of a full thickness one. The CTG was placed buccally using partial thickness or full thickness flap according to the randomization schedule. The width of keratinized tissue (KT), the horizontal soft tissue thickness (STT), the marginal hard and soft tissue levels as well as the implant success parameters were collected and analyzed.
After a 3 year follow-up period the increase of KT was statistically significantly (p < 0.001) larger in the partial thickness group from 0.6(0.6) to 5.1(0.72) mm, while full thickness group showed very little improvement from 0.5(0.51) to 1(0.57) mm (p < 0.001). STT was significantly increased in both groups over time: from 2.4(0.88) to 5.4(0.68) mm in full thickness group and from 2.5(0.51) to 5.8(0.41) mm in partial thickness group without any significant difference between the groups.
The increase of soft tissue thickness by using CTG from tuberosity was found in both groups, while keratinization of non-keratinized mucosa appeared more in the partial thickness group.
有研究表明,从结节区获取的结缔组织移植物(CTG)易引发过度增生反应,并可能促进非角化黏膜的有益过度角化。本研究旨在评估并比较在牙槽嵴骨量不足的无牙下颌中,采用翻瓣或全层瓣制备受区后,CTG 从结节区获取的增加软组织厚度和角化潜能的能力。
本研究纳入了 10 名牙槽嵴萎缩(Misch 分类 IV 类)、角化组织厚度小于 1.0mm 的无牙下颌患者,共 40 枚种植体,采用无瓣技术植入,即刻以多单位基台修复丙烯酸临时桥。将手术部位随机分为双侧,采用隧道式手术制备 CTG 受区。其中 20 例采用部分厚度瓣,20 例采用全层瓣。根据随机分组方案,将 CTG 置于颊侧,采用部分或全层瓣。收集角化组织宽度(KT)、水平软组织厚度(STT)、边缘软硬组织水平以及种植体成功参数,并进行分析。
在 3 年的随访期内,部分厚度组 KT 增加量显著大于全层组(0.6(0.6)至 5.1(0.72)mm,p<0.001),而全层组仅略有改善(0.5(0.51)至 1(0.57)mm,p<0.001)。两组的 STT 均随时间显著增加:全层组从 2.4(0.88)至 5.4(0.68)mm,部分厚度组从 2.5(0.51)至 5.8(0.41)mm,两组间无显著差异。
两组均发现使用来自结节区的 CTG 可增加软组织厚度,而部分厚度组的非角化黏膜角化程度更高。