瓜拉那、特蕾和马黛茶在合法的技术制备和饮用模式下：巴拉圭冬青最常饮用的饮料的化学成分、抗氧化、抗炎和抗焦虑特性的比较研究
Chimarrão, terere and mate-tea in legitimate technology modes of preparation and consume: A comparative study of chemical composition, antioxidant, anti-inflammatory and anti-anxiety properties of the mostly consumed beverages of Ilex paraguariensis St. Hil.
机构信息
Institute of Biology, Department of Plant Biology, PPG BCE, University of Campinas (UNICAMP), 13083-970, Campinas, São Paulo, Brazil.
College of Health Science, Federal University of Grande Dourados, Dourados, MS, Brazil.
出版信息
J Ethnopharmacol. 2021 Oct 28;279:114401. doi: 10.1016/j.jep.2021.114401. Epub 2021 Jul 7.
ETHNOPHARMACOLOGICAL RELEVANCE
Ilex paraguariensis St. Hil. (Aquifoliaceae) is a medicinal plant widely used by South American populations for centuries and is popularly attributed to stimulating and detoxifying properties. Nowadays, their consume traditionally occurs through three different beverages: chimarrão, terere and mate-tea.
AIM OF THE STUDY
Although its composition and properties are well studied, literature lacks work comparing the potential of their extracts obtained by a legitimate preparation mode of their popular beverages. Therefore, the purpose of this research is to investigate changes in chemical composition, antioxidant activity, anti-inflammatory efficacy and anxiolytic effect from lyophilized aqueous extracts obtained simulating the legitimate popular preparation mode of chimarrão, terere and mate-tea.
MATERIALS AND METHODS
In this work, were investigated differences related to preparation technology and dry material used through chemical composition analysis, with the lyophilized aqueous extracts obtained simulating the chimarrão, terere and mate-tea preparation. The chemical composition analysis comprises the total soluble phenolics content, chemical profiles by HPLC-ESI-MS/MS, and quantitative component detection by HPLC-UV/DAD. Moreover, evaluations of comparative antioxidant activity of the extracts (DPPH and ORAC assays), anti-inflammatory efficacy and anxiolytic effect were performed in vivo.
RESULTS
Our results showed that chimarrão extracts presented a richer composition in terms of phenolic compounds and purine alkaloids, and better antioxidant activity when compared to the other extracts. In pleurisy test, all products showed anti-inflammatory properties in the dose of 60 mg/kg. In the anxiolytic evaluation, although all extracts presented some effect, chimarrão and terere were better than mate-tea in general. No sign of toxicity was observed.
CONCLUSIONS
Our findings support that the beverage made as chimarrão has the best composition and the most promising properties overall.
植物药用途
巴拉圭冬青（冬青科）是一种药用植物，在南美洲被广泛应用了几个世纪，被认为具有刺激和解毒作用。如今，其传统上通过三种不同的饮料来消费：奇玛拉诺茶、特雷雷茶和马黛茶。
研究目的
尽管其成分和特性已得到充分研究，但文献中缺乏比较通过合法制备模式获得的其提取物的潜在用途的工作，这些合法制备模式来自于奇玛拉诺茶、特雷雷茶和马黛茶等流行饮料。因此，本研究的目的是调查通过模拟奇玛拉诺茶、特雷雷茶和马黛茶的合法流行制备模式获得的冻干水提物的化学成分、抗氧化活性、抗炎效果和抗焦虑作用的变化。
材料和方法
在这项工作中，通过化学成分分析，调查了与制备技术和干燥材料有关的差异，使用的是模拟奇玛拉诺茶、特雷雷茶和马黛茶制备方法的冻干水提物。化学成分分析包括总可溶性酚含量、通过 HPLC-ESI-MS/MS 的化学特征图谱以及通过 HPLC-UV/DAD 的定量成分检测。此外，还进行了比较提取物的抗氧化活性（DPPH 和 ORAC 测定）、抗炎效果和抗焦虑作用的评估。
结果
我们的结果表明，与其他提取物相比，奇玛拉诺茶提取物在酚类化合物和嘌呤生物碱方面的组成更丰富，抗氧化活性更好。在胸膜炎试验中，所有产品在 60mg/kg 的剂量下均表现出抗炎作用。在焦虑评估中，尽管所有提取物都有一定的作用，但奇玛拉诺茶和特雷雷茶总体上优于马黛茶。未观察到毒性迹象。
结论
我们的发现支持这样的观点，即奇玛拉诺茶制成的饮料具有最佳的成分和最有前途的特性。
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