卵巢子宫切除术对母犬尿液中 5-羟色胺、皮质醇、睾酮和孕酮的短期影响。
Short-term effect of ovariohysterectomy on urine serotonin, cortisol, testosterone and progesterone in bitches.
机构信息
Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, PO Box 7011, 750 07, Uppsala, Sweden.
Department of Clinical Sciences, Swedish University of Agricultural Sciences, PO Box 7054, 750 07, Uppsala, Sweden.
出版信息
BMC Res Notes. 2021 Jul 10;14(1):265. doi: 10.1186/s13104-021-05680-y.
OBJECTIVE
This study aimed to investigate the short-term effect of ovariohysterectomy on urine levels of serotonin and its relation to levels of cortisol, testosterone and progesterone in female dogs. Seven bitches were studied before surgical ovariohysterectomy and then once a week during 4 weeks. Spontaneously voided urine samples were collected and concentration ratios of hormone/creatinine in urine were analysed.
RESULTS
The bitches had significantly lower levels of cortisol, testosterone, and progesterone 1 week after ovariohysterectomy compared with before and the levels stayed low throughout the study (P ≤ 0.05). Interestingly, serotonin levels tended to increase 4 weeks after surgery (P = 0.08). A positive correlation between cortisol and progesterone was found before and after surgery. After surgery, serotonin was positively correlated with cortisol and progesterone (P ≤ 0.05).
目的
本研究旨在探讨卵巢子宫切除术对雌性犬尿液中 5-羟色胺水平的短期影响及其与皮质醇、睾酮和孕酮水平的关系。7 只母犬在手术前和手术后的 4 周内每周进行一次研究。收集自发性排尿的尿液样本，并分析尿液中激素/肌酐的浓度比值。
结果
卵巢子宫切除术后 1 周，母犬的皮质醇、睾酮和孕酮水平明显低于手术前，整个研究期间水平较低（P≤0.05）。有趣的是，术后 4 周 5-羟色胺水平有升高趋势（P=0.08）。术前和术后发现皮质醇和孕酮之间呈正相关。术后，5-羟色胺与皮质醇和孕酮呈正相关（P≤0.05）。
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