Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France.
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France.
Trends Immunol. 2021 Aug;42(8):654-657. doi: 10.1016/j.it.2021.06.008. Epub 2021 Jul 7.
Broadly neutralizing antibodies against rapidly evolving viruses (e.g., HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly evolving viruses. We propose that polyreactivity contributes to toleration of viral variants and shortens the time for generating neutralizing antibodies.
广谱中和抗体针对快速进化的病毒（例如 HIV-1 和流感病毒），通常表现出抗原结合的广谱性。基于最近的一项研究，我们假设抗体的多反应性在中和快速进化的病毒方面的重要性。我们提出，多反应性有助于耐受病毒变异体，并缩短产生中和抗体的时间。
