Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Ave, Vancouver, WA, 98686, USA.
Psychopharmacology (Berl). 2021 Oct;238(10):2895-2903. doi: 10.1007/s00213-021-05906-8. Epub 2021 Jul 10.
Social support and opioid replacement therapy are commonly used to treat opioid withdrawal.
The present study tested the hypothesis that social housing and buprenorphine administration can restore wheel running depressed by morphine withdrawal in rats.
Experiment 1 assessed disruptive side effects of buprenorphine and found that administration of low doses (3.2, 10, & 32 µg/kg, s.c.) had no impact on voluntary wheel running. Experiment 2 assessed the impact of social housing and acute buprenorphine administration (10 µg/kg) on morphine withdrawal. Two 75 mg morphine pellets were implanted for 3 days to induce dependence. Removal of the morphine pellets caused a decrease in body weight, increase in wet dog shakes, and depression of wheel running during the normally active dark phase of the circadian cycle. Social housing restored wheel running and reduced the number of wet dog shakes but did not affect body weight. Administration of buprenorphine restored wheel running depressed by morphine withdrawal for 2 days in individually housed rats and produced time-dependent changes in socially housed rats: Depression of wheel running in the 3 h following administration and restoration of running subsequently compared to saline-treated controls.
The impact of buprenorphine and social housing to reduce the effect of morphine withdrawal in rats is consistent with the use of opioid substitution therapy and psychotherapy/social support to treat opioid withdrawal in humans. These data provide further validation for the clinical relevance for the use of wheel running to assess spontaneous opioid withdrawal.
社会支持和阿片类药物替代疗法常用于治疗阿片类药物戒断。
本研究检验了以下假设，即社会住房和丁丙诺啡给药可以恢复吗啡戒断引起的大鼠转轮运动减少。
实验 1 评估了丁丙诺啡的破坏性行为副作用，发现给予低剂量（3.2、10 和 32µg/kg，皮下）对自愿转轮运动没有影响。实验 2 评估了社会住房和急性丁丙诺啡给药（10µg/kg）对吗啡戒断的影响。两个 75mg 吗啡丸植入 3 天以诱导依赖性。去除吗啡丸会导致体重下降、湿狗抖动增加以及在昼夜节律的正常活动暗相中转轮运动减少。社会住房恢复了转轮运动并减少了湿狗抖动的次数，但对体重没有影响。丁丙诺啡给药恢复了吗啡戒断引起的转轮运动减少，在单独饲养的大鼠中持续 2 天，并在社会饲养的大鼠中产生时间依赖性变化：给药后 3 小时转轮运动减少，随后恢复运动与盐水治疗对照组相比。
丁丙诺啡和社会住房对减少大鼠吗啡戒断影响的作用与阿片类药物替代疗法和心理治疗/社会支持治疗人类阿片类药物戒断的作用一致。这些数据进一步验证了使用转轮运动评估自发性阿片类药物戒断的临床相关性。
