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解决阿片类药物危机：在镇痛药物发现中选择转化终点的重要性。

Addressing the Opioid Crisis: The Importance of Choosing Translational Endpoints in Analgesic Drug Discovery.

机构信息

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond VA, USA.

出版信息

Trends Pharmacol Sci. 2018 Apr;39(4):327-330. doi: 10.1016/j.tips.2018.02.002. Epub 2018 Feb 28.

DOI:10.1016/j.tips.2018.02.002
PMID:29501211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5869150/
Abstract

The opioid crisis has stimulated renewed interest in analgesic drug development. This effort will involve preclinical-to-clinical translational research and will benefit from a focus on endpoints that are both clinically relevant and shared across laboratory animals and humans. Measures of pain-related functional impairment and behavioral depression could serve this purpose.

摘要

阿片类药物危机刺激了人们对镇痛药物开发的重新关注。这一努力将涉及临床前到临床的转化研究，并将受益于关注临床相关且在实验室动物和人类中共享的终点。与疼痛相关的功能障碍和行为抑郁的测量可以达到这一目的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb9/5869150/22cdadb8aaad/nihms943847f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb9/5869150/37a9c75d7b9d/nihms943847f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb9/5869150/22cdadb8aaad/nihms943847f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb9/5869150/37a9c75d7b9d/nihms943847f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb9/5869150/22cdadb8aaad/nihms943847f2.jpg

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