Park Da Hee, Fuge Jan, Meltendorf Tanja, Kahl Kai G, Richter Manuel J, Gall Henning, Ghofrani Hossein A, Kamp Jan C, Hoeper Marius M, Olsson Karen M
Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Front Psychiatry. 2021 Jun 24;12:668647. doi: 10.3389/fpsyt.2021.668647. eCollection 2021.
Covid-19 pandemic may affect mental health and quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). We assessed changes in anxiety and depression, quality of life (QoL) and self-described impact of Covid-19 in patients with PAH during the Covid-19 pandemic. This study included 152 patients with PAH from two German referral centers. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D) at two different timepoints before and during the Covid-19 pandemic with a median of 232 days between baseline and follow-up. QoL was assessed using EQ-5D and emPHasis-10. Perceived impact of Covid-19 and related regulations and measures were assessed using a set of specific questions and statements. More than two thirds of patients had an unsuspicious HADS-A and HADS-D. Median scores did not differ from baseline for both HADS-A and HADS-D ( = 0.202; = 0.621). Overall, no significant changes in HADS-A or HADS-D categories from baseline to follow up were observed ( = 0.07; = 0.13). QoL did not change between baseline and follow-up. The Covid-19 pandemic had little impact on access to medical care and established PAH therapy. Patients were in agreement with governmental measures and regulations and felt sufficiently safe. First waves of Covid-19 pandemic had little impact on anxiety, depression and QoL in patient with PAH. Established PAH therapy and access to medical care were not affected. Further studies on the impact of prolonged duration of the ongoing Covid-19 pandemic are needed.
新冠疫情可能会影响肺动脉高压（PAH）患者的心理健康和生活质量（QoL）。我们评估了新冠疫情期间PAH患者焦虑和抑郁的变化、生活质量以及新冠疫情对其自我描述的影响。本研究纳入了来自德国两个转诊中心的152例PAH患者。在新冠疫情之前和期间的两个不同时间点，使用医院焦虑抑郁量表（HADS - A和HADS - D）评估焦虑和抑郁情况，基线与随访之间的中位数时间间隔为232天。使用EQ - 5D和emPHasis - 10评估生活质量。使用一组特定问题和陈述评估新冠疫情及其相关规定和措施的感知影响。超过三分之二的患者HADS - A和HADS - D结果正常。HADS - A和HADS - D的中位数得分与基线相比无差异（= 0.202；= 0.621）。总体而言，从基线到随访，HADS - A或HADS - D类别未观察到显著变化（= 0.07；= 0.13）。基线和随访之间生活质量没有变化。新冠疫情对获得医疗护理和既定的PAH治疗影响很小。患者同意政府的措施和规定，并感到足够安全。新冠疫情的第一波对PAH患者的焦虑、抑郁和生活质量影响很小。既定的PAH治疗和获得医疗护理未受影响。需要进一步研究新冠疫情持续时间延长所产生的影响。
