Ma Yu-Shui, Liu Ji-Bin, Yang Xiao-Li, Xin Rui, Shi Yi, Zhang Dan-Dan, Wang Hui-Min, Wang Pei-Yao, Lin Qin-Lu, Li Wen, Fu Da
National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology Changsha 410004, Hunan, China.
Cancer Institute, Nantong Tumor Hospital Nantong 226631, China.
Am J Cancer Res. 2021 Jun 15;11(6):2386-2400. eCollection 2021.
Chemotherapy is one of the main treatments for cancer, especially for advanced cancer patients. In the past decade, significant progress has been made with the research into the molecular mechanisms of cancer cells and the precision medicine. The treatment on cancer patients has gradually changed from cytotoxic chemotherapy to precise treatment strategy. Research into anticancer drugs has also changed from killing effects on all cells to targeting drugs for target genes. Besides, researchers have developed the understanding of the abnormal physiological function, related genomics, epigenetics, and proteomics of cancer cells with cancer genome sequencing, epigenetic research, and proteomic research. These technologies and related research have accelerated the development of related cancer drugs. In this review, we summarize the research progress of anticancer drugs, the current challenges, and future opportunities.
化疗是癌症的主要治疗方法之一，尤其适用于晚期癌症患者。在过去十年中，癌细胞分子机制和精准医学的研究取得了重大进展。对癌症患者的治疗已逐渐从细胞毒性化疗转变为精准治疗策略。抗癌药物的研究也从对所有细胞的杀伤作用转变为针对靶基因的靶向药物。此外，通过癌症基因组测序、表观遗传学研究和蛋白质组学研究，研究人员对癌细胞异常的生理功能、相关基因组学、表观遗传学和蛋白质组学有了更深入的了解。这些技术及相关研究加速了相关抗癌药物的开发。在本综述中，我们总结了抗癌药物的研究进展、当前面临的挑战及未来的机遇。
