Almohsen Shahd S, Alnuaim Hala, Salim Alaa A, Arabi Haitham
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard ‑ Health Affairs, Riyadh, SAU.
Cureus. 2021 Jun 3;13(6):e15428. doi: 10.7759/cureus.15428. eCollection 2021 Jun.
Radiation-induced sarcomas (RIS) are a rare long-term complication of radiation therapy, with a reported incidence of 2.5-5.5%. They usually develop several years following exposure to radiotherapy. The most common reported subtypes are undifferentiated pleomorphic sarcoma, angiosarcoma, and leiomyosarcoma. Breast cancer is the most common primary malignancy preceding RIS, followed by uterine cervical carcinoma. Only a few cases of RIS with rhabdomyoblastic differentiation have been reported in the literature, usually following the treatment of retinoblastoma. Herein, we report a rare case of RIS with rhabdomyoblastic differentiation in the pelvic region developing 12 years after cervical cancer radiation therapy.
放射性诱导肉瘤（RIS）是放射治疗一种罕见的长期并发症，报告发病率为2.5%-5.5%。它们通常在接受放射治疗数年之后发生。报告的最常见亚型是未分化多形性肉瘤、血管肉瘤和平滑肌肉瘤。乳腺癌是RIS之前最常见的原发性恶性肿瘤，其次是子宫颈癌。文献中仅报道了少数几例具有横纹肌母细胞分化的RIS病例，通常是在视网膜母细胞瘤治疗之后。在此，我们报告1例罕见的盆腔区域具有横纹肌母细胞分化的RIS病例，该病例在宫颈癌放射治疗12年后发生。
