一种源自……的天然二萜类化合物的抗肿瘤活性及作用机制
The Antitumor Activity and Mechanism of a Natural Diterpenoid From .
作者信息
Li Ying, Ma Jun, Song Ziteng, Zhao Yinan, Zhang Han, Li Yeling, Xu Jing, Guo Yuanqiang
机构信息
State Key Laboratory of Medicinal Chemistry Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin, China.
出版信息
Front Oncol. 2021 Jun 25;11:688195. doi: 10.3389/fonc.2021.688195. eCollection 2021.
Casearlucin A, a diterpenoid obtained from , has been reported to possess strong cytotoxic activity. However, the anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish . More importantly, casearlucin A significantly inhibited cell proliferation and migration in an zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent.
从[来源未给出]中获得的二萜类化合物Casearlucin A已被报道具有很强的细胞毒性活性。然而，Casearlucin A的抗肿瘤作用及其作用机制仍知之甚少。我们的研究表明，Casearlucin A在细胞水平上使细胞周期停滞在G0/G1期并诱导细胞凋亡。此外，Casearlucin A通过调节一些与转移相关的蛋白质来抑制HepG2细胞迁移。此外，它在斑马鱼中抑制肿瘤血管生成。更重要的是，Casearlucin A在斑马鱼异种移植模型中显著抑制细胞增殖和迁移。总的来说，这些结果对于Casearlucin A作为抗癌剂的进一步开发和应用具有重要价值。
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