Ghorbani Hamidreza, Zarifmahmoudi Leili, Sadeghi Ramin, Soltani Salman, Aghaee Atena
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Asia Ocean J Nucl Med Biol. 2021 Spring;9(2):177-179. doi: 10.22038/AOJNMB.2021.54064.1370.
The effectiveness of the sentinel lymph node mapping in patients with Urothelial carcinoma of the bladder is under investigation. Single photon emission computed tomography (SPECT/CT) and intraoperative sentinel node biopsy using gamma probe are performed to detect the exact location of the sentinel lymph node to be dissected during the surgery. In this case report, a 73-year old man with high grade urothelial carcinoma was referred to our nuclear medicine department for SPECT/CT, four hours after injection of the radiotracer through cystoscopy. SPECT/CT could not reveal any sentinel node; however, one sentinel lymph node was detected and harvested in the right external iliac region during surgery. SPECT/CT revealed unusual accumulation of tracer in large bowel which was due to severe adhesion of rectum and bladder, and inadvertent injection of the radiotracer into the rectal wall. During the sentinel lymph node procedure, the tracer should be injected with extreme caution and lymphoscintigraphy post injection may help detection of any injection failures.
前哨淋巴结定位在膀胱尿路上皮癌患者中的有效性正在研究中。采用单光子发射计算机断层扫描(SPECT/CT)和术中使用γ探头进行前哨淋巴结活检,以确定手术中要切除的前哨淋巴结的确切位置。在本病例报告中,一名患有高级别尿路上皮癌的73岁男性,在通过膀胱镜注射放射性示踪剂4小时后,被转诊至我们核医学科进行SPECT/CT检查。SPECT/CT未发现任何前哨淋巴结;然而,手术期间在右髂外区域发现并切除了一个前哨淋巴结。SPECT/CT显示示踪剂在大肠中异常聚集,这是由于直肠与膀胱严重粘连,以及放射性示踪剂意外注入直肠壁所致。在前哨淋巴结手术过程中,注射示踪剂时应格外小心,注射后进行淋巴闪烁显像可能有助于发现任何注射失败情况。