Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J Infect Dis. 2022 Feb 1;225(3):465-469. doi: 10.1093/infdis/jiab366.
Persons with isolated antibody to hepatits B virus (HBV) core antigen (IAHBc) may have occult HBV infection (OBI), which is associated with reactivation and potential risk for hepatocellular carcinoma and HBV transmission. We used National Health and Nutrition Examination Survey data to estimate US IAHBc prevalence and published studies of IAHBc-associated OBI prevalence to estimate OBI burden. During 2001-2018, the prevalence of IAHBc was 0.8% (approximately 2.1 million persons), and the OBI burden range was 35 500-83 600 persons. These data support the need for more robust estimates of IAHBc-associated OBI prevalence in the general US population.
具有乙型肝炎病毒（HBV）核心抗原（HBcAg）抗体的个体（IAHBc）可能存在隐匿性 HBV 感染（OBI），这与 HBV 再激活和潜在的肝细胞癌风险以及 HBV 传播有关。我们使用国家健康和营养调查数据来估计美国 IAHBc 的流行率，并根据 IAHBc 相关 OBI 流行率的已发表研究来估计 OBI 负担。在 2001 年至 2018 年期间，IAHBc 的流行率为 0.8%（约 210 万人），OBI 负担范围为 35500-83600 人。这些数据支持需要更准确地估计美国一般人群中 IAHBc 相关 OBI 的流行率。
