Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; Mercy Health - Cincinnati Sports Medicine and Orthopaedic Center, Cincinnati, Ohio, U.S.A.
Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Arthroscopy. 2022 Mar;38(3):818-830.e1. doi: 10.1016/j.arthro.2021.06.026. Epub 2021 Jul 9.
To determine whether arthroscopic osteochondroplasty demonstrated effectiveness in a pragmatic femoroacetabular impingement patient population embedded within FIRST (the Femoroacetabular Impingement RandomiSed controlled Trial).
All cohort patients were not randomized and were followed prospectively with a follow-up assessment protocol identical to that in FIRST. The primary outcome was hip pain using a 100-point visual analog scale. Secondary outcomes included hip function (Hip Outcome Score, International Hip Outcome Tool-12), health utility (EuroQol 5 Dimensions), and health-related quality of life (Short Form-12) at 12 months, as well as operatively and nonoperatively treated hip complications at 24 months. We performed multivariable regressions to compare these outcomes between 3 groups of patients: (1) those randomized to lavage in FIRST, (2) those randomized to osteochondroplasty in FIRST, and (3) those who received osteochondroplasty as part of the cohort study.
All groups had improvements across all questionnaire outcomes from baseline to 12 months, with no significant differences. There were significantly more reoperations in the lavage trial group compared with those in the embedded cohort (adjusted odds ratio [aOR] 3.08; 95% confidence interval [CI] 1.23-7.73; P = .016). There were significantly more nonoperatively treated hip complications in the lavage trial group and in the osteochondroplasty trial group when compared with those in the embedded cohort (aOR 3.81; 95% CI 1.19-12.17; P = .024 and aOR 4.55; 95% CI 1.43-14.42; P = .010, respectively).
Hip arthroscopic osteochondroplasty and lavage led to improvement in hip pain, function, and health-related quality of life at 12 months across both randomized controlled trial (RCT) and cohort patients. The pragmatic cohort receiving osteochondroplasty had (1) significantly fewer complications than RCT patients, (2) significantly less reoperations than RCT patients randomized to arthroscopic lavage, and (3) fewer, although nonsignificant, reoperations than RCT osteochondroplasty patients.
II, therapeutic.
在嵌入 FIRST(髋关节撞击随机对照试验)的实用型髋关节撞击症患者人群中,确定关节镜下骨软骨成形术是否有效。
所有队列患者均未随机分组,前瞻性随访,随访评估方案与 FIRST 相同。主要结局为采用 100 分视觉模拟评分法(VAS)评估的髋痛。次要结局包括髋关节功能(髋关节结局评分、国际髋关节结局工具-12 评分)、健康效用(EuroQol 5 维度)和健康相关生活质量(SF-12 短量表)在 12 个月时的情况,以及在 24 个月时手术和非手术治疗的髋关节并发症情况。我们进行多变量回归分析,以比较三组患者的这些结局:(1)在 FIRST 中随机分配至冲洗组的患者,(2)在 FIRST 中随机分配至骨软骨成形术组的患者,以及(3)作为队列研究一部分接受骨软骨成形术的患者。
所有组在基线至 12 个月时所有问卷结局均有改善,且无显著差异。冲洗组的再手术率明显高于队列组(校正优势比[aOR]3.08;95%置信区间[CI]1.23-7.73;P=.016)。冲洗组和骨软骨成形术组的非手术治疗髋关节并发症明显多于队列组(aOR 3.81;95%CI 1.19-12.17;P=.024 和 aOR 4.55;95%CI 1.43-14.42;P=.010)。
髋关节镜下骨软骨成形术和冲洗在随机对照试验(RCT)和队列患者中均能在 12 个月时改善髋痛、功能和健康相关生活质量。接受骨软骨成形术的实用型队列患者(1)并发症发生率明显低于 RCT 患者,(2)接受关节镜冲洗术的 RCT 患者再手术率明显低于 RCT 患者,(3)尽管差异无统计学意义,但再手术率也明显低于 RCT 骨软骨成形术患者。
II,治疗性。