Department of Aerospace Physiology, Fourth Military Medical University, 169(#) Changle West Road, Xi'an, 710032, China; Department of Internal Medicine, Affiliated Hospital of Xizang Minzu University, Xianyang, 712082, China.
Department of Aerospace Physiology, Fourth Military Medical University, 169(#) Changle West Road, Xi'an, 710032, China.
Biochem Biophys Res Commun. 2021 Sep 10;569:161-166. doi: 10.1016/j.bbrc.2021.06.099. Epub 2021 Jul 9.
Acute high-altitude illness seriously threatens the health and lives of people who rapidly ascend to high altitudes, but there is currently no particularly effective method for the prevention or treatment of acute high-altitude illness. In the present study, we found that fasting preconditioning effectively improved the survival rate of rats exposed to a simulated altitude of 7620 m for 24 h, and a novel animal model of rapid adaptation to acute hypoxia was established. Compared with control treatment, fasting preconditioning activated AMPK, induced autophagy, decreased ROS levels, and inhibited NF-κB signaling in the cardiac tissues of rats. Our results suggested that fasting effectively improved the acute hypoxia tolerance of rats, which was gradually enhanced with prolongation of fasting. In addition, the acute hypoxia tolerance of young rats was significantly higher than that of adult rats. These experimental results lay the foundation for achieving rapid adaptation to acute hypoxia in humans.
急性高原病严重威胁着快速进入高海拔地区人群的健康和生命，但目前尚无特别有效的预防或治疗急性高原病的方法。在本研究中，我们发现禁食预处理可有效提高暴露于模拟海拔 7620 米环境 24 小时的大鼠的存活率，并建立了一个快速适应急性低氧的新型动物模型。与对照处理相比，禁食预处理激活了 AMPK，诱导了自噬，降低了心脏组织中的 ROS 水平，并抑制了 NF-κB 信号通路。我们的结果表明，禁食可有效提高大鼠的急性低氧耐受能力，并且随着禁食时间的延长而逐渐增强。此外，年轻大鼠的急性低氧耐受能力明显高于成年大鼠。这些实验结果为在人类中实现快速适应急性低氧奠定了基础。
