Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of ophthalmology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Ophthalmol. 2021 Jul 12;21(1):274. doi: 10.1186/s12886-021-02033-y.
To report Stevens-Johnson syndrome (SJS) in a patient with acute pneumonia secondary to SARS-CoV-2 infection.
A 45-years-old woman with a diagnosis of acute pneumonia secondary to SARS-CoV-2 infection who had received azithromycin and naproxen. Three days after starting the medication, she appeared ill and developed ocular discomfort, photophobia, dysuria, and macular rashes on the trunk and the extremities. On ophthalmological examination, a total epithelial defect was seen in both eyes. According to the examination, Stevens-Johnson syndrome was diagnosed and the patient was admitted to receive systemic and ocular support and medical care. The patient's condition improved during the 3 weeks and recovered from both COVID-19 and SJS life-threatening complications but ocular complications, including the destruction of the meibomian glands, irregularity of the eyelid margin, and corneal scarring remained for the patient.
Although, it is not clear whether the cause of Stevens-Johnson syndrome in COVID-19 patients is the virus itself or whether the use of medication, but patients with COVID-19, especially patients receiving medication, should be screened for symptoms of Stevens-Johnson syndrome.
报告 1 例继发于 SARS-CoV-2 感染的急性肺炎患者出现史蒂文斯-约翰逊综合征（SJS）。
1 名 45 岁女性，诊断为继发于 SARS-CoV-2 感染的急性肺炎，曾接受阿奇霉素和萘普生治疗。用药 3 天后，患者出现不适，出现眼部不适、畏光、尿痛和躯干及四肢的斑丘疹。眼科检查显示双眼完全上皮缺损。根据检查结果，诊断为史蒂文斯-约翰逊综合征，患者住院接受全身和眼部支持及治疗。患者在 3 周内病情好转，COVID-19 和 SJS 危及生命的并发症均得到治愈，但遗留眼部并发症，包括睑板腺破坏、眼睑边缘不规则和角膜瘢痕。
虽然目前尚不清楚 COVID-19 患者发生 SJS 的原因是病毒本身还是药物使用，但 COVID-19 患者，尤其是接受药物治疗的患者，应筛查史蒂文斯-约翰逊综合征的症状。
