Temes G, Lantos J, Török B
Department of Experimental Surgery, University Medical School, Pécs, Hungary.
Acta Physiol Hung. 1987;70(1):93-103.
The changes of aortic blood pressure (BP), carotid artery flow (CAF), power spectrum of analysed EEG, neurologic deficit and survival rate were determinated in dogs after experimental cardiac arrest of different duration. Following artificially induced ventricular fibrillation of 1, 4, 10, 12 and 15 min duration successful cardiopulmonary resuscitation was performed in 30 experimental animals. Alterations of power spectrum during and after reanimation procedures, severity of the neurologic state and the survival rate deteriorated in parallel with the increasing duration of circulatory stop. Advantageous effect of direct heart massage could be demonstrated by the measuring circulatory parameters. Following a 15 min fibrillation, all animals were lost in a few hours despite the successful restoration of circulation and ventilation. Considering the various experimental and clinical conditions experimental cardiac arrest lasting for 12 min seems to be useful in extrapolating the results to human cases. The suggested model allows to study the brain function recovery after circulatory stop and resuscitation.
在不同时长的实验性心脏骤停后的犬类中，测定主动脉血压（BP）、颈动脉血流（CAF）、分析脑电图的功率谱、神经功能缺损及存活率的变化。在30只实验动物中，分别诱导持续1、4、10、12和15分钟的室颤后，成功进行了心肺复苏。复苏过程中及复苏后的功率谱变化、神经状态的严重程度和存活率均随着循环停止时间的延长而恶化。通过测量循环参数可证明直接心脏按摩的有益效果。在15分钟的室颤后，尽管循环和通气已成功恢复，但所有动物在数小时内均死亡。考虑到各种实验和临床情况，持续12分钟的实验性心脏骤停似乎有助于将结果外推至人类病例。所建议的模型可用于研究循环停止和复苏后脑功能的恢复情况。
