Department of Pediatrics, Erzurum Training and Research Hospital, Erzurum, Turkey.
Department of Pediatric Dentistry, Hacettepe University Faculty of Dentistry, Ankara, Turkey.
Turk J Pediatr. 2021;63(3):443-449. doi: 10.24953/turkjped.2021.03.011.
Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory disease. We aimed to investigate the oral health status and oral hygiene habits in children with FMF.
In this cross-sectional study, 199 children with FMF, aged between 3-18 years, were included. Demographic findings and oral hygiene habits of children were questioned by face-to-face interview. Oral health status of patients was evaluated using decay-missing-filled index [DMFT (decay-missing-filled teeth), DMFS (decay-missing-filled teeth) for permanent; dmft, dmfs for primary teeth], the International Caries Detection and Assessment System (ICDAS-II) index, PUFA / pufa index [the presence of severely decayed teeth with visible pulpal involvement (P/p), ulceration caused by dislocated tooth fragments (U/u), fistula (F/f) and abscess (A/a)], gingival (GI) and plaque index (PI). In addition to these, occlusion, oral soft and hard tissues were examined.
One-hundred-nine (54.8%) of children had at least one decayed permanent tooth and 81.2% of children had at least one decayed primary tooth. The mean DMFT was 1.91±2.45, DMFS was 3.1±4.49, dmft was 3.95±3.54, dmfs was 8.62±8.88, PI was 1.17±0.44, GI was 0.85±0.39. Aphthous mouth ulcer occurred in 19 (9.5%) patients. Recurrent aphthous mouth ulcers were more frequent among patients with one exon-ten and one exon-two mutations than patients with one exon-10 mutation, two exon-ten mutations, or two exon-2 mutations (61.1% vs. 47.9%, 26.1%, 20%, respectively p < 0.001). Tooth decay was more frequent among patients who had attacks in the last six months than those who did not have any attacks during the last six months (97.4% vs. 87.7%, p=0.017).
Dental caries and periodontal disease, which are public health problems, were seen at a high percentage of children with FMF in our study.
家族性地中海热（FMF）是最常见的遗传性自身炎症性疾病。我们旨在研究 FMF 患儿的口腔健康状况和口腔卫生习惯。
在这项横断面研究中，纳入了 199 名年龄在 3-18 岁之间的 FMF 患儿。通过面对面访谈询问儿童的人口统计学发现和口腔卫生习惯。通过龋齿-缺失-充填指数[DMFT（恒牙龋齿-缺失-充填），DMFS（恒牙龋齿-缺失-充填）；dmft，dmfs 用于乳牙]、国际龋病检测和评估系统（ICDAS-II）指数、PUFA / pufa 指数[严重龋坏牙伴可见牙髓受累（P/p）、脱位牙碎片引起的溃疡（U/u）、瘘管（F/f）和脓肿（A/a）]、牙龈（GI）和菌斑指数（PI）评估患者的口腔健康状况。此外，还检查了咬合、口腔软硬组织。
109 名（54.8%）儿童至少有一颗恒牙龋坏，81.2%的儿童至少有一颗乳牙龋坏。平均 DMFT 为 1.91±2.45，DMFS 为 3.1±4.49，dmft 为 3.95±3.54，dmfs 为 8.62±8.88，PI 为 1.17±0.44，GI 为 0.85±0.39。19 名（9.5%）患儿出现口疮性口炎。与仅携带一个外显子 10 突变和一个外显子 2 突变的患者相比，携带一个外显子 10 和一个外显子 2 突变、两个外显子 10 突变或两个外显子 2 突变的患者复发性口疮性口炎更为常见（61.1%比 47.9%、26.1%、20%，均 p<0.001）。在过去 6 个月中有发作的患儿中，龋齿的发生率高于在过去 6 个月中无发作的患儿（97.4%比 87.7%，p=0.017）。
在我们的研究中，FMF 患儿中出现了高比例的龋齿和牙周病等公共卫生问题。
