Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, North Goa, Goa India, 403110.
J Org Chem. 2021 Aug 6;86(15):10812-10818. doi: 10.1021/acs.joc.1c01039. Epub 2021 Jul 13.
The synthesis of differently substituted 2,3,4-triarylcyclopent-2-en-1-ones from 2-cyclopentenone via sequential functionalization of a novel 2,4-dibromo-3-(4-methoxyphenyl) cyclopent-2-en-1-one intermediate has been developed. The process provides access to selective arylation at C-4 and C-2 with a broader substrates scope, which includes heteroaryl and alkyl substitution at C-2.
通过新型 2,4-二溴-3-(4-甲氧基苯基)环戊-2-烯-1-酮中间体的顺序官能化，从 2-环戊烯酮合成了不同取代的 2,3,4-三芳基环戊-2-烯-1-酮。该过程提供了在 C-4 和 C-2 处选择性芳基化的途径，底物范围更广，包括 C-2 处的杂芳基和烷基取代基。
