Viljoen D, Beighton P
Department of Human Genetics, Medical School, University of Cape Town, South Africa.
Am J Med Genet. 1987 Aug;27(4):907-12. doi: 10.1002/ajmg.1320270417.
In a survey of institutions for crippled persons in Zimbabwe, 58 patients with osteogenesis imperfecta (OI) were identified; 42 had the rare OI Type III. The Shona and Ndebele people, who comprise the major tribal groups in Zimbabwe, both had a similar and relatively high gene frequency for this disorder. Both tribes were derived from common progenitors, but until 150 years ago had been geographically separated for 2 millenia. Subsequently, they have remained culturally and socially distinct. The implications are that the mutation for OI III in Africa occurred at least 2,000 years ago.
在对津巴布韦残疾人机构的一项调查中，确认了58例成骨不全症（OI）患者；其中42例患罕见的III型OI。绍纳族和恩德贝莱族是津巴布韦的主要部落群体，这两个群体中该疾病的基因频率相似且相对较高。这两个部落都源自共同的祖先，但直到150年前，他们在地理上已经分隔了2000年。随后，他们在文化和社会方面一直保持着差异。这意味着非洲的III型OI突变至少发生在2000年前。
