Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
Cancer Cell. 2021 Jul 12;39(7):913-915. doi: 10.1016/j.ccell.2021.06.013.
Three articles in Nature show that intestinal stem cells with cancer-promoting mutations could shape the surrounding normal tissue in their favor to promote clonal fixation and field expansion, raising the possibility of developing therapeutic strategies that maintain or enhance the health of normal cells to out-compete the mutant cells.
《自然》杂志上的三篇文章表明，具有致癌突变的肠道干细胞可以通过有利于自身的方式塑造周围的正常组织，促进克隆固定和领域扩张，这增加了开发维持或增强正常细胞健康以与突变细胞竞争的治疗策略的可能性。
