Department of Pathology, The University of Hong Kong, Pok Fu Lam, Hong Kong.
State Key Laboratory of Liver Research, (The University of Hong Kong), Pok Fu Lam, Hong Kong.
Pathol Oncol Res. 2021 Jun 4;27:1609752. doi: 10.3389/pore.2021.1609752. eCollection 2021.
The liver is the commonest site of cancer metastasis. In this study, we asked whether the immune tumor microenvironment in liver metastases was governed by the β-catenin activation status of the tumor. To this end, we analyzed CD8 and FoxP3 immunohistochemical expression against β-catenin expression status of the tumor in a cohort of 52 liver samples with metastatic carcinoma. The results showed that colorectal primary constituted the largest proportion of metastatic carcinoma showing β-catenin overexpression. Intra-tumoral CD8 count was lower and FoxP3 count was higher when compared with the non-tumoral liver parenchyma. β-catenin overexpression was associated with a lower CD8 count in the tumor region ( = 0.003). In summary, our findings are in support of an altered immune tumor microenvironment vs. the non-tumor liver tissues in the metastatic site. Suppression of CD8 count was associated with activated Wnt/β-catenin signaling in the metastatic tumor.
肝脏是癌症转移最常见的部位。在这项研究中，我们想知道肿瘤β-catenin 激活状态是否控制着肝转移灶中的免疫肿瘤微环境。为此，我们分析了 52 例转移性癌肝脏样本中肿瘤β-catenin 表达状态与 CD8 和 FoxP3 免疫组织化学表达之间的关系。结果表明，结直肠原发癌构成了β-catenin 过表达的转移性癌的最大比例。与非肿瘤性肝实质相比，肿瘤内 CD8 计数较低，FoxP3 计数较高。β-catenin 过表达与肿瘤区域 CD8 计数较低相关（=0.003）。总之，我们的研究结果支持转移性部位的免疫肿瘤微环境与非肿瘤性肝组织不同。CD8 计数的抑制与转移瘤中激活的 Wnt/β-catenin 信号通路有关。
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