Department of Child Psychiatry and Rehabilitation, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
MGH/HST Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 1118A, Charlestown, MA 02129, USA.
Neural Plast. 2021 Jun 19;2021:6627507. doi: 10.1155/2021/6627507. eCollection 2021.
Recently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and the Repetitive Behavior Scale-Revised (RBS-R). We found that children with ASD can tolerate three-week tDCS treatment with no serious adverse events detected. A within-group comparison showed that real tDCS, but not sham tDCS, can significantly reduce the scores of CARS, Children's Sleep Habits Questionnaire (CSHQ), and general impressions in CARS (15th item). Real tDCS produced significant score reduction in the CSHQ and in CARS general impressions when compared to the effects of sham tDCS. The pilot study suggests that three-week left DLPFC tDCS is well-tolerated and may hold potential in relieving some symptoms in children with ASD.
最近，经颅直流电刺激（tDCS）已被应用于缓解自闭症谱系障碍（ASD）患者的症状。在这项前瞻性、平行、单盲、随机研究中，我们研究了为期三周的左背外侧前额叶皮质（DLPFC）tDCS 治疗对 ASD 儿童的调节作用。共纳入 47 名 ASD 儿童，其中 40 名（每组 20 名）完成了研究。主要结局指标为儿童自闭症评定量表（CARS）、异常行为检查表（ABC）和重复行为量表修订版（RBS-R）。我们发现 ASD 儿童可以耐受为期三周的 tDCS 治疗，未发现严重不良事件。组内比较显示，真实 tDCS，而不是假 tDCS，可以显著降低 CARS、儿童睡眠习惯问卷（CSHQ）和 CARS 一般印象（第 15 项）的评分。与假 tDCS 相比，真实 tDCS 可显著降低 CSHQ 和 CARS 一般印象的评分。这项初步研究表明，为期三周的左 DLPFC tDCS 耐受性良好，可能有潜力缓解 ASD 儿童的一些症状。
Zotero 插件