Department of Neurosurgery, American University of Beirut Medical Center, 2033 9105 Beirut, Lebanon.
Faculty of Medicine, Lebanese University, 2033 9105 Beirut, Lebanon.
J Integr Neurosci. 2021 Jun 30;20(2):489-497. doi: 10.31083/j.jin2002052.
Most of the debilitating conditions following aneurysmal subarachnoid hemorrhage result from symptomatic cerebral vasospasm and delayed cerebral ischemia. Several scales are being used, but they still lack objectivity and fail to quantify complications considered essential for prognostication routine use of biomarkers to predict complications and outcomes after aneurysmal rupture is still experimental. Degradomics were studied extensively in traumatic brain injury, but there is no discussion of these biomarkers related to aneurysmal subarachnoid hemorrhage. Degradomics involve the activation of proteases that target specific substrates and generate specific protein fragments called degradomes. While the proteolytic activities constitute the pillar of development, growth, and regeneration of tissues, dysregulated proteolysis resulting from pathological conditions like aneurysmal subarachnoid hemorrhage ends up in apoptotic processes and necrosis. To our knowledge, this is the first overview that lists a panel of degradomics with cut-off values in serum and cerebrospinal fluid, where specificity and sensitivity are only found in Kallikrein 6, Ubiquitin C Terminal Hydrolase 1 and Alpha-II-Spectrin.
大多数蛛网膜下腔出血后导致身体虚弱的情况是由于症状性脑血管痉挛和迟发性脑缺血所致。目前有几种评分量表正在使用，但它们仍然缺乏客观性，无法量化对预后很重要的并发症。生物标志物常规用于预测蛛网膜下腔出血破裂后的并发症和结果仍处于实验阶段。降解组学在创伤性脑损伤中得到了广泛研究，但没有讨论与蛛网膜下腔出血相关的这些生物标志物。降解组学涉及蛋白酶的激活，这些蛋白酶针对特定的底物，并产生特定的蛋白质片段，称为降解组。虽然蛋白酶的活性构成了组织发育、生长和再生的支柱，但由于蛛网膜下腔出血等病理状况导致的蛋白质水解失调最终会导致细胞凋亡和坏死。据我们所知，这是第一个列出了一组血清和脑脊液中具有截断值的降解组学的综述，其中只有激肽释放酶 6、泛素 C 端水解酶 1 和α-Ⅱ- spectrin 具有特异性和敏感性。
