Department of Medicine, Division of Gastroenterology and Hepatology, Penn State University College of Medicine, Hershey, PA, USA.
Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
Inflamm Bowel Dis. 2022 Jun 3;28(6):850-854. doi: 10.1093/ibd/izab175.
Several studies have reported an association between inflammatory bowel disease (IBD) and Parkinson's disease (PD). The aim of this study is to re-evaluate for an association between IBD and PD while controlling for potential socioeconomic and environmental confounders.
We performed a retrospective cohort study using the Truven Health Marketscan database between January 1, 2005, and December 31, 2014. Individuals with IBD and household age-matched controls were identified. Adjusted hazard ratios (HRs) were calculated for the development of incident PD, adjusting for age, sex, residence type, US region, comorbidities, and behavior.
In all, 154 051 subjects with IBD and an equal number of controls were identified. During a mean (SD) follow-up of 3.8 (2.2) years, 132 incident PD cases were identified. There was no significant association between IBD and PD (adjusted HR, 1.01; 0.72-1.42) when adjusting for the confounders previously mentioned.
We found no statistically significant association between these disorders. It is possible that previous associations identified between these disorders were confounded by environmental and socioeconomic factors.
几项研究报告称炎症性肠病（IBD）与帕金森病（PD）之间存在关联。本研究的目的是在控制潜在的社会经济和环境混杂因素的情况下，重新评估 IBD 与 PD 之间的关联。
我们使用 Truven Health Marketscan 数据库进行了一项回顾性队列研究，时间范围为 2005 年 1 月 1 日至 2014 年 12 月 31 日。确定了患有 IBD 的个体和家庭年龄匹配的对照组。通过调整年龄、性别、居住类型、美国地区、合并症和行为等因素，计算了发生 PD 的调整后的风险比（HR）。
总共确定了 154051 例 IBD 患者和相同数量的对照组。在平均（SD）随访 3.8（2.2）年后，发现了 132 例 PD 新发病例。在调整上述混杂因素后，IBD 与 PD 之间无显著相关性（调整后的 HR，1.01；0.72-1.42）。
我们未发现这两种疾病之间存在统计学显著的关联。以前确定的这些疾病之间的关联可能受到环境和社会经济因素的混杂。
