Demard F, Schneider M, Chauvel P, Ramaioli A, Vallicioni J, Santini J
Centre Antoine-Lacassagne, Nice.
Ann Otolaryngol Chir Cervicofac. 1987;104(6):399-406.
150 patients were treated at the Centre Antoine-Lacassagne by CDDP-5 FU induction chemotherapy. Amongst the 134 cases suitable for evaluation, there were 86.6% of greater than 50% responses including 45.5% complete responses (CR). These clinical findings led to changes in post-chemotherapy protocol, mutilating surgical procedures such as total laryngectomy being replaced in complete responders by radiotherapy only. These changes did not lead to any alteration in the survival of the patients. The degree of tumour control at 1 and 2 years was 91.4% and 81.4% for complete responses, 74.6% and 60.6% for partial responses (PR) with survival rates of 1 and 2 years 94% and 78.3% for CR and 77% and 55.1% for PR. The possibility of conservative treatment with a high level of reliability would alone appear to be justification for the use of induction chemotherapy in cervico-facial oncology.
150例患者在安托万 - 拉卡萨涅中心接受顺铂 - 5氟尿嘧啶诱导化疗。在134例适合评估的病例中，超过50%反应的病例占86.6%，其中完全缓解（CR）率为45.5%。这些临床结果导致化疗后方案发生改变，对于完全缓解者，诸如全喉切除术等致残性手术被仅用放射治疗所取代。这些改变并未导致患者生存率的任何改变。完全缓解者1年和2年时的肿瘤控制率分别为91.4%和81.4%，部分缓解（PR）者分别为74.6%和60.6%，CR者1年和2年生存率分别为94%和78.3%，PR者分别为77%和55.1%。仅保守治疗具有高度可靠性这一可能性似乎就足以成为在头颈面部肿瘤学中使用诱导化疗的理由。
