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头皮大恶性黑素瘤病例,采用 5%咪喹莫特乳膏和 3.75%咪喹莫特乳膏治疗。

Case of large lentigo maligna melanoma of the scalp treated with 5% and 3.75% Imiquimod.

机构信息

Department of Dermatology, University of Parma, Parma, Italy.

Department of Dermatology, University of Parma, Parma, Italy.

出版信息

An Bras Dermatol. 2021 Sep-Oct;96(5):565-568. doi: 10.1016/j.abd.2020.08.025. Epub 2021 Jul 12.

DOI:10.1016/j.abd.2020.08.025
PMID:34261602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8441514/
Abstract

The paper presents a case of lentigo maligna melanoma of the scalp in an elderly patient treated for the nodular part with surgery and the residual melanoma in situ with 5% Imiquimod and subsequently with 3.75% Imiquimod (each concentration for 4 months, 5 times per week), with complete regression of the lesion. 3.75% Imiquimod, which is already used for the treatment of actinic keratosis, could be a useful weapon with the same effectiveness and fewer side effects compared to 5% Imiquimod.

摘要

本文报告了一例头皮恶性黑素瘤病例,患者为老年患者,结节部分采用手术治疗,残余原位黑素瘤采用 5%咪喹莫特和随后的 3.75%咪喹莫特(每浓度治疗 4 个月,每周 5 次)治疗,病变完全消退。3.75%咪喹莫特已用于治疗光化性角化病,与 5%咪喹莫特相比,它具有相同的疗效和更少的副作用,可能是一种有用的武器。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/5ed071a2e99d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/7730538f0595/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/34aadea2a757/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/597a00f69467/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/5ed071a2e99d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/7730538f0595/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/34aadea2a757/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/597a00f69467/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d83/8441514/5ed071a2e99d/gr4.jpg

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Case of large lentigo maligna melanoma of the scalp treated with 5% and 3.75% Imiquimod.头皮大恶性黑素瘤病例,采用 5%咪喹莫特乳膏和 3.75%咪喹莫特乳膏治疗。
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引用本文的文献

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本文引用的文献

1
Clinical usefulness of dermoscopy in the management of lentigo maligna melanoma treated with topical imiquimod: A case report.临床应用皮肤镜在咪喹莫特治疗恶性雀斑样痣黑素瘤中的作用:一例报告。
Dermatol Ther. 2019 Sep;32(5):e13048. doi: 10.1111/dth.13048. Epub 2019 Aug 12.
2
Effectiveness of 5% Topical Imiquimod for Lentigo Maligna Treatment.5%外用咪喹莫特治疗恶性雀斑样痣的疗效。
Acta Derm Venereol. 2019 Sep 1;99(10):884-888. doi: 10.2340/00015555-3241.
3
An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.
一种使用咪喹莫特外用治疗头颈部原位黑色素瘤残留灶的管理算法:一项初步研究。
Ann Plast Surg. 2019 Apr;82(4S Suppl 3):S199-S201. doi: 10.1097/SAP.0000000000001840.
4
Lentigo Maligna-Challenges, Observations, Imiquimod, Confocal Microscopy, and Personalized Treatment.恶性雀斑样痣——挑战、观察、咪喹莫特、共聚焦显微镜检查及个性化治疗
JAMA Dermatol. 2018 Aug 1;154(8):879-881. doi: 10.1001/jamadermatol.2018.0531.
5
A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures.咪喹莫特在恶性雀斑样痣及恶性雀斑样痣黑色素瘤中作用的系统评价:治疗方案和疗效评估标准化的必要性
J Eur Acad Dermatol Venereol. 2017 Apr;31(4):616-624. doi: 10.1111/jdv.14085. Epub 2017 Jan 23.
6
Five-year recurrence rate of lentigo maligna after treatment with imiquimod.咪喹莫特治疗后恶性雀斑样痣的五年复发率。
Br J Dermatol. 2016 Jan;174(1):165-8. doi: 10.1111/bjd.14311. Epub 2015 Dec 23.
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Dermoscopic and clinical features of head and neck melanoma.头颈部黑色素瘤的皮肤镜及临床特征
An Bras Dermatol. 2015 Jul-Aug;90(4):488-93. doi: 10.1590/abd1806-4841.20153341.
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Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: two phase 3, multicenter, randomized, double-blind, placebo-controlled studies.咪喹莫特2.5%和3.75%用于治疗光化性角化病:两项3期、多中心、随机、双盲、安慰剂对照研究。
J Drugs Dermatol. 2014 Feb;13(2):166-9.
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Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-week cycles.咪喹莫特 2.5% 和 3.75% 乳膏用于治疗光化性角化病:两项为期 2 周、每日应用于面部和脱发头皮的安慰剂对照研究的结果。
J Am Acad Dermatol. 2010 Apr;62(4):582-90. doi: 10.1016/j.jaad.2009.07.004. Epub 2010 Feb 4.
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Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline.黑色素瘤的诊断和治疗:基于欧洲共识的跨学科指南。
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