Kurochkina V B, Sokal'skaia L I, Zhukovskaia S A, Zhukova N G, Libinson G S
Antibiot Med Biotekhnol. 1987 Oct;32(10):743-7.
Benzylpenicillin interaction with amines in the nonaqueous phase was studied by pH dependence of the coefficient of the antibiotic distribution in the system of amine butyl acetate solution--water. A distribution scheme involving interaction of the amine molecular and cationic forms with benzylpenicillin and amine dissociation equilibrium in organic solution is described. On the basis of the experimental data the interaction and dissociation constants were determined for a number of aromatic and aliphatic amines.
通过研究苄青霉素在胺-乙酸丁酯溶液-水体系中抗生素分配系数的pH依赖性，对非水相中苄青霉素与胺的相互作用进行了研究。描述了一种分配方案，该方案涉及胺的分子形式和阳离子形式与苄青霉素的相互作用以及有机溶液中的胺解离平衡。根据实验数据，确定了多种芳香胺和脂肪胺的相互作用常数和解离常数。
