Chen Dan, Wang Min, Duan Luxi, Chen Xi, Zhang Qiang, Li Xingli
Xiang Ya School of Public Health, Central South University, Changsha, Hunan 410078, People's Republic of China.
Institute for HIV/AIDS, The First Hospital of Changsha, Changsha, Hunan 410011, People's Republic of China.
Trans R Soc Trop Med Hyg. 2022 Mar 2;116(3):213-221. doi: 10.1093/trstmh/trab101.
There is little research to date in the area of quality of life (QoL) among older Chinese people living with HIV/AIDS (PLWHA). This study aims to explore the QoL and its influential factors among older PLWHA in China.
Cross-sectional data of 242 adults with HIV/AIDS aged 50-84 y from Hunan were analyzed to evaluate the associations of demographic characteristics, illness-related factors, HIV-related stigma and social support with QoL. The WHO QOL-HIV BREF questionnaire was used to measure QoL on six domains (physical, psychological, independence, social relationships, environment and spirituality).
A total of 242 older PLWHA completed the survey, of whom 150 (62.0%) were males. Multivariate linear regression analyses identified that females, side effects of highly active antiretroviral therapy, chronic non-communicable diseases and higher levels of perceived negative self-image were negatively associated with QoL, especially in the physical, independence and spirituality domains; whereas higher education or annual income, retired and elevated levels of subjective social support or support availability were positively associated with QoL, especially in the psychological, independence, social relationships and environment domains.
The study findings suggest that interventions to improve QoL should focus on reducing HIV-related stigma and side effects and on enhancing economic situations and social support.
迄今为止，针对中国老年艾滋病毒/艾滋病感染者（PLWHA）的生活质量（QoL）领域的研究较少。本研究旨在探讨中国老年PLWHA的生活质量及其影响因素。
分析了来自湖南的242名年龄在50 - 84岁的艾滋病毒/艾滋病成年患者的横断面数据，以评估人口统计学特征、疾病相关因素、与艾滋病毒相关的耻辱感和社会支持与生活质量之间的关联。使用世界卫生组织生活质量艾滋病毒简表问卷来测量六个领域（身体、心理、独立性、社会关系、环境和精神性）的生活质量。
共有242名老年PLWHA完成了调查，其中150名（62.0%）为男性。多变量线性回归分析确定，女性、高效抗逆转录病毒治疗的副作用、慢性非传染性疾病以及较高水平的负面自我认知与生活质量呈负相关，尤其是在身体、独立性和精神性领域；而较高的教育程度或年收入、退休以及较高水平的主观社会支持或支持可得性与生活质量呈正相关，尤其是在心理、独立性、社会关系和环境领域。
研究结果表明，改善生活质量的干预措施应侧重于减少与艾滋病毒相关的耻辱感和副作用，并改善经济状况和社会支持。
