患有李-佛美尼综合征的儿科患者中伴有H3F3A G34R突变或MYCN扩增的恶性胶质瘤。 - Suppr

Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome.

作者信息

Schoof Melanie, Kordes Uwe, Volk Alexander E, Al-Kershi Sina, Kresbach Catena, Schüller Ulrich

机构信息

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.

出版信息

Acta Neuropathol. 2021 Sep;142(3):591-593. doi: 10.1007/s00401-021-02346-8. Epub 2021 Jul 15.

DOI:10.1007/s00401-021-02346-8

PMID:34264394

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8357758/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d7/8357758/c715e540026d/401_2021_2346_Fig1_HTML.jpg

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Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features.

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An update on the central nervous system manifestations of Li-Fraumeni syndrome.

Acta Neuropathol. 2020 Apr;139(4):669-687. doi: 10.1007/s00401-019-02055-3. Epub 2019 Aug 30.

DNA methylation-based classification of central nervous system tumours.

Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14.

H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers.

Acta Neuropathol. 2017 Sep;134(3):507-516. doi: 10.1007/s00401-017-1710-1. Epub 2017 Apr 11.

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.

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Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome.

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